LILRB2

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2

Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles (PubMed:11169396, PubMed:12853576, PubMed:16455647, PubMed:20448110, PubMed:27859042).
Involved in the down-regulation of the immune response and the development of tolerance. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance (PubMed:20448110, PubMed:27859042, PubMed:16455647).
Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:11875462, PubMed:12853576, PubMed:9548455, PubMed:9842885).

Adaptive immune responseIEA:UniProtKB-KW
Cell surface receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Cellular defense responseManual Assertion Based On ExperimentTAS:ProtInc
Cellular response to lipopolysaccharideManual Assertion Based On ExperimentIMP:BHF-UCL
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Fc receptor mediated inhibitory signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Heterotypic cell-cell adhesionManual Assertion Based On ExperimentIDA:BHF-UCL
Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Immune response-inhibiting cell surface receptor signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Interleukin-10-mediated signaling pathwayManual Assertion Based On ExperimentIEP:ARUK-UCL
Learning or memoryBy SimilarityISS:ARUK-UCL
Negative regulation of antigen processing and presentationManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of calcium ion transportManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of postsynaptic density organizationIC:ARUK-UCL
Negative regulation of protein metabolic processBy SimilarityISS:ARUK-UCL
Negative regulation of T cell costimulationManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of T cell proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of interleukin-6 production1 PublicationNAS:BHF-UCL
Positive regulation of long-term synaptic depressionBy SimilarityISS:ARUK-UCL
Positive regulation of protein dephosphorylationBy SimilarityISS:ARUK-UCL
Positive regulation of regulatory T cell differentiationManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of T cell proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of T cell tolerance inductionManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of tolerance inductionManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of dendritic cell differentiation1 PublicationIC:BHF-UCL
Regulation of long-term synaptic potentiationBy SimilarityISS:ARUK-UCL
Signal transductionManual Assertion Based On ExperimentIDA:BHF-UCL

Cell membrane

Extracellular: 22-460
Helical: 461-481
Cytoplasmic: 482-597

Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6.