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Mouse Anti-LILRB2 Recombinant Antibody (11) (CBMAB-L1563-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
11
Antibody Isotype
IgG2b
Application
FC

Basic Information

Immunogen
Recombinant Human LILRB2/ILT4/LIR-2 Protein.
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
Introduction
LILRB2 is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. LILRB2 belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Innate Immune System. Gene Ontology (GO) annotations related to this gene include protein phosphatase 1 binding. An important paralog of this gene is LILRB1.
Entrez Gene ID
10288
UniProt ID
Q8N423
Alternative Names
ILT4; LIR2; CD85D; ILT-4; LIR-2; MIR10; MIR-10
Function
Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles (PubMed:11169396, PubMed:12853576, PubMed:16455647, PubMed:20448110, PubMed:27859042).
Involved in the down-regulation of the immune response and the development of tolerance. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance (PubMed:20448110, PubMed:27859042, PubMed:16455647).
Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:11875462, PubMed:12853576, PubMed:9548455, PubMed:9842885).
Biological Process
Adaptive immune responseIEA:UniProtKB-KW
Cell surface receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Cellular defense responseManual Assertion Based On ExperimentTAS:ProtInc
Cellular response to lipopolysaccharideManual Assertion Based On ExperimentIMP:BHF-UCL
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Fc receptor mediated inhibitory signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Heterotypic cell-cell adhesionManual Assertion Based On ExperimentIDA:BHF-UCL
Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Immune response-inhibiting cell surface receptor signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Interleukin-10-mediated signaling pathwayManual Assertion Based On ExperimentIEP:ARUK-UCL
Learning or memoryBy SimilarityISS:ARUK-UCL
Negative regulation of antigen processing and presentationManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of calcium ion transportManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of postsynaptic density organizationIC:ARUK-UCL
Negative regulation of protein metabolic processBy SimilarityISS:ARUK-UCL
Negative regulation of T cell costimulationManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of T cell proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of interleukin-6 production1 PublicationNAS:BHF-UCL
Positive regulation of long-term synaptic depressionBy SimilarityISS:ARUK-UCL
Positive regulation of protein dephosphorylationBy SimilarityISS:ARUK-UCL
Positive regulation of regulatory T cell differentiationManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of T cell proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of T cell tolerance inductionManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of tolerance inductionManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of dendritic cell differentiation1 PublicationIC:BHF-UCL
Regulation of long-term synaptic potentiationBy SimilarityISS:ARUK-UCL
Signal transductionManual Assertion Based On ExperimentIDA:BHF-UCL
Cellular Location
Cell membrane
Topology
Extracellular: 22-460
Helical: 461-481
Cytoplasmic: 482-597
PTM
Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6.
More Infomation

Umiker, B., Hashambhoy-Ramsay, Y., Smith, J., Rahman, T., Mueller, A., Davidson, R., ... & Shaffer, D. R. (2023). Inhibition of LILRB2 by a Novel Blocking Antibody Designed to Reprogram Immunosuppressive Macrophages to Drive T-Cell Activation in Tumors. Molecular Cancer Therapeutics, 22(4), 471-484.

Zhao, P., Xu, Y., Jiang, L. L., Fan, X., Ku, Z., Li, L., ... & An, Z. (2022). LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions. Molecular neurodegeneration, 17(1), 44.

Nishiyama, S., Hirose, N., Yanoshita, M., Takano, M., Kubo, N., Yamauchi, Y., ... & Tanimoto, K. (2021). ANGPTL2 induces synovial inflammation via LILRB2. Inflammation, 44, 1108-1118.

Wang, Q., Song, H., Cheng, H., Qi, J., Nam, G., Tan, S., ... & Gao, G. F. (2020). Structures of the four Ig-like domain LILRB2 and the four-domain LILRB1 and HLA-G1 complex. Cellular & Molecular Immunology, 17(9), 966-975.

Yanovsky, R. L., Chen, H., Leslie, S., Carrington, M., & Liao, W. (2020). The interaction of LILRB2 with HLA-B is associated with psoriasis susceptibility. The Journal of investigative dermatology, 140(6), 1292.

Shao, H., Ma, L., Jin, F., Zhou, Y., Tao, M., & Teng, Y. (2018). Immune inhibitory receptor LILRB2 is critical for the endometrial cancer progression. Biochemical and biophysical research communications, 506(1), 243-250.

Chen, H. M., van der Touw, W., Wang, Y. S., Kang, K., Mai, S., Zhang, J., ... & Chen, S. H. (2018). Blocking immunoinhibitory receptor LILRB2 reprograms tumor-associated myeloid cells and promotes antitumor immunity. The Journal of clinical investigation, 128(12), 5647-5662.

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For research use only. Not intended for any clinical use.

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