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LGALS3

This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. The protein exhibits antimicrobial activity against bacteria and fungi. Alternate splicing results in multiple transcript variants.
Full Name
galectin 3
Alternative Names
L31; GAL3; MAC2; CBP35; GALBP; GALIG; LGALS2
Function
Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity).
In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes.
Biological Process
Antimicrobial humoral immune response mediated by antimicrobial peptideIDA:UniProtKB
Eosinophil chemotaxisManual Assertion Based On ExperimentIDA:BHF-UCL
Epithelial cell differentiationManual Assertion Based On ExperimentIEP:UniProtKB
Innate immune responseIEA:UniProtKB-KW
Killing of cells of other organismIDA:UniProtKB
Macrophage chemotaxisManual Assertion Based On ExperimentIDA:BHF-UCL
Monocyte chemotaxisManual Assertion Based On ExperimentIDA:BHF-UCL
Mononuclear cell migrationManual Assertion Based On ExperimentIDA:BHF-UCL
mRNA processingIEA:UniProtKB-KW
Negative regulation of endocytosisManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of extrinsic apoptotic signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of immunological synapse formationBy SimilarityISS:BHF-UCL
Negative regulation of protein tyrosine phosphatase activity1 PublicationIC:ARUK-UCL
Negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cellBy SimilarityISS:BHF-UCL
Negative regulation of T cell receptor signaling pathwayBy SimilarityISS:BHF-UCL
Neutrophil chemotaxisManual Assertion Based On ExperimentIDA:BHF-UCL
Positive chemotaxisManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of calcium ion importManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of mononuclear cell migrationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of protein localization to plasma membraneManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of protein-containing complex assemblyManual Assertion Based On ExperimentIDA:ARUK-UCL
Regulation of extrinsic apoptotic signaling pathway via death domain receptorsManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of T cell apoptotic processManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of T cell proliferationManual Assertion Based On ExperimentIMP:BHF-UCL
RNA splicingIEA:UniProtKB-KW
Cellular Location
Cytoplasm
Nucleus
Secreted
Secreted by a non-classical secretory pathway and associates with the cell surface. Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059).

Anti-LGALS3 antibodies

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Target: LGALS3
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBYCL-265
Application*: WB, IC, P, C, E
Target: Lgals3
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYJL-2421
Application*: WB
Target: Lgals3
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: M3/38
Application*: E, FC, C, P
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-1516
Application*: P, WB
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-1515
Application*: IF, WB
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: 357
Application*: ELISA, IF, IHC, WB
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CAP938
Application*: ELISA, IHC
Target: Lgals3
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: B1249M
Application*: IC, IH, IP, WB
Target: Lgals3
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYJL-2419
Application*: WB
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CAP936
Application*: IHC
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: CBYJL-1522
Application*: E, IF, IH, WB, siRNA
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-1521
Application*: P
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJL-1520
Application*: F, IF, P, WB
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: B2C10
Application*: F, FN, C, P, WB
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9C7
Application*: P, WB
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJL-1519
Application*: WB, IH
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 87B5
Application*: F, WB
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-1518
Application*: IH, WB
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 6E1
Application*: P, WB
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5F9-C7-F10-A11
Application*: E
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3G8
Application*: E, IF, WB
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJL-1517
Application*: E, P, IP, WB
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 38B2
Application*: IH, WB
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6G2
Application*: WB, IH
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 8D7
Application*: E, P, WB
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 320CT4.5.2
Application*: E, IH, WB
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 23D12
Application*: P, WB
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYCL-264
Application*: WB, IC, P, C, E
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 21D10
Application*: WB
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 21C1
Application*: P, WB
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1G8
Application*: IF, P, WB
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBLG1-2365
Application*: E (IA), WB
Target: LGALS3
Host: Human
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBLG1-2364
Application*: F, F
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-1513
Application*: IF, P, WB
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-1512
Application*: WB
Target: LGALS3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-1511
Application*: E, ED
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 15E4
Application*: P, WB
Target: LGALS3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-1510
Application*: P
Target: LGALS3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-1509
Application*: WB, IP
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-1508
Application*: EC
Target: LGALS3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-1507
Application*: F, IC, IF
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-1506
Application*: WB, E, IP
Target: LGALS3
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYH-2623
Application*: F
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYH-2622
Application*: F
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2621
Application*: P
Target: LGALS3
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBFYH-2619
Application*: WB
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBFYH-2618
Application*: WB, IF
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Rabbit
Clone: A3A12
Application*: E, IC, IF, C, P, WB
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYCL-263
Application*: IH, WB
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYCL-262
Application*: E, IH, IP, WB
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBYCL-261
Application*: WB, IH
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-2366
Application*: WB
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: B-E53
Application*: E
Target: LGALS3
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: B1621M
Application*: F
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG
Specificity: Cattle, Human, Mouse, Rat
Clone: CBLG1-2363
Application*: IF, IH, WB
Target: LGALS3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-2359
Application*: WB
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-2357
Application*: IH, WB
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-2354
Application*: IH
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-2353
Application*: WB
Target: LGALS3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-2352
Application*: P
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBLG1-2350
Application*: E (IA), WB
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBLG1-2349
Application*: WB
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBLG1-2348
Application*: WB
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Cattle
Clone: CBLG1-2347
Application*: WB
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-2346
Application*: E, WB
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBLG1-2345
Application*: IA, IC/IF, C, P, WB
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBLG1-2344
Application*: WB
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-2343
Application*: WB
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-2341
Application*: IH
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: ZG001
Application*: E, IH, WB
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: UMAB189
Application*: IH
Target: LGALS3
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse, Human
Clone: RM0082-5L36
Application*: WB
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-3075
Application*: WB
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: Gal397
Application*: WB
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBLG1-3225
Application*: WB
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9
Application*: WB
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 194801
Application*: F
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 194804
Application*: WB
Target: LGALS3
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 202213
Application*: WB
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 5C21
Application*: WB
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9C4
Application*: P
Target: LGALS3
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse
Clone: eBioM3/38M3/38
Application*: F
Target: LGALS3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-3073
Application*: WB
Target: LGALS3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-3074
Application*: IC/IF
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1
Application*: E, WB
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: 14L453
Application*: WB
Target: LGALS3
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 14L454
Application*: WB
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG
Specificity: Cattle, Human, Mouse, Rat
Clone: 15H199
Application*: IF, WB
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 16E6
Application*: E, IH
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: V2-69630
Application*: WB
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 1H4
Application*: E, IH
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2B1
Application*: WB
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 2F9
Application*: P
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: 3F25
Application*: WB
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rabbit, Rat
Clone: 4i288
Application*: E, IC, IF, IH, WB
Target: LGALS3
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 5L36
Application*: WB
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 6B8
Application*: E, IH
Target: LGALS3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 6D408
Application*: E, F
Target: LGALS3
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse
Clone: CB1249
Application*: E, ICC, IH, IP, WB
Target: LGALS3
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CB1621
Application*: E, FC
More Infomation
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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