LDB2

LIM-domain binding family are characterized by a conserved nuclear localization sequence, an amino-terminal homodimerization domain and a carboxy-terminal LIM interaction domain. LDB2 (LIM domain binding 2) belongs to the LIM-domain binding family. LDB2 may function in rhegmatogenous retinal detachment and coronary artery disease.

LDB2

Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors.

Epithelial structure maintenanceIEA:Ensembl
Hair follicle developmentIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Nervous system developmentManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cellular component biogenesisIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell migrationISS:UniProtKB
Regulation of kinase activityISS:UniProtKB
Somatic stem cell population maintenanceIEA:Ensembl

Nucleus

Ubiquitinated by RLIM/RNF12, leading to its degradation by the proteasome.