Mouse Anti-LDB2 Recombinant Antibody (CBYCL-181) (CBMAB-L0082-YC)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBYCL-181

Antibody Isotype

IgG1

Application

ELISA, ICC, WB

Basic Information

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH7.4, with 0.09% sodium azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 1-374

Target

Full Name

LDB2

Introduction

LDB2 belongs to the LIM-domain binding family. Members of this family are characterized by a conserved nuclear localization sequence, an amino-terminal homodimerization domain and a carboxy-terminal LIM interaction domain. These proteins function as adapter molecules to allow assembly of transcriptional regulatory complexes. Genetic association studies suggest functions for this gene in rhegmatogenous retinal detachment and coronary artery disease.

Entrez Gene ID

9079

UniProt ID

O43679

Alternative Names

CLIM1; LDB-2; LDB1

Function

Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors.

Biological Process

Epithelial structure maintenanceIEA:Ensembl
Hair follicle developmentIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Nervous system developmentManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cellular component biogenesisIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell migrationISS:UniProtKB
Regulation of kinase activityISS:UniProtKB
Somatic stem cell population maintenanceIEA:Ensembl

Cellular Location

Nucleus

PTM

Ubiquitinated by RLIM/RNF12, leading to its degradation by the proteasome.

More Infomation

References

Chu, F., Xu, X., Zhang, Y., Cai, H., Peng, J., Li, Y., ... & Chen, X. (2023). LIM-domain binding protein 2 was down-regulated by miRNA-96-5p inhibited the proliferation, invasion and metastasis of lung cancer H1299 cells. Clinics, 78.

Zhai, D., Wang, G., Li, L., Jia, X., Zheng, G., & Yin, J. (2021). LIM-domain binding protein 2 regulated by m 6 A modification inhibits lung adenocarcinoma cell proliferation in vitro. Nan Fang yi ke da xue xue bao= Journal of Southern Medical University, 41(3), 329-335.

Ohnishi, T., Kiyama, Y., Arima‐Yoshida, F., Kadota, M., Ichikawa, T., Yamada, K., ... & Yoshikawa, T. (2021). Cooperation of LIM domain‐binding 2 (LDB2) with EGR in the pathogenesis of schizophrenia. EMBO Molecular Medicine, 13(4), e12574.

Choi, H. J., Rho, S. S., Choi, D. H., & Kwon, Y. G. (2018). LDB2 regulates the expression of DLL4 through the formation of oligomeric complexes in endothelial cells. BMB reports, 51(1), 21.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-LDB2 Recombinant Antibody (1A3)

Mouse Anti-LDB2 Antibody (1A10)

Mouse Anti-LDB2 Recombinant Antibody (CBYJL-1330)

Mouse Anti-LDB2 Recombinant Antibody (1C3)

Mouse Anti-LDB2 Recombinant Antibody (CBYCL-180)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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SDS
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