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LAM

Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. This protein may have a role in the localization of the LEM domain proteins Ote, bocks and MAN1 to the nuclear membrane. In spermatocytes, plays a role in maintaining type-A lamin LamC nuclear localization; regulates meiotic cytokinesis by maintaining the structure of the spindle envelope, and by contributing to the formation of the contractile ring and central spindle.
Full Name
Lam
Function
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin (PubMed:3126192, PubMed:15035436).
May have a role in the localization of the LEM domain proteins Ote, bocks and MAN1 to the nuclear membrane (PubMed:15035436, PubMed:16439308).
In spermatocytes, plays a role in maintaining type-A lamin LamC nuclear localization; regulates meiotic cytokinesis by maintaining the structure of the spindle envelope, and by contributing to the formation of the contractile ring and central spindle (PubMed:27402967).
Required for nuclear migration and to link the microtubule organizing center (MTOC) to the nucleus (PubMed:14617811).
In addition, is required for nuclear envelope localization of klar (PubMed:14617811).
Biological Process
Adult locomotory behaviorManual Assertion Based On ExperimentIMP:FlyBase
Cell agingManual Assertion Based On ExperimentIMP:FlyBase
Central nervous system developmentManual Assertion Based On ExperimentIMP:FlyBase
Chitin-based cuticle developmentManual Assertion Based On ExperimentIMP:FlyBase
Compound eye morphogenesisManual Assertion Based On ExperimentIMP:FlyBase
Digestive tract morphogenesisManual Assertion Based On ExperimentIMP:FlyBase
Gonad morphogenesisManual Assertion Based On ExperimentIMP:FlyBase
Heterochromatin assemblyManual Assertion Based On ExperimentIDA:FlyBase
Heterochromatin organizationManual Assertion Based On ExperimentIMP:FlyBase
Male meiosis cytokinesisManual Assertion Based On ExperimentIMP:UniProtKB
Meiosis I cytokinesisManual Assertion Based On ExperimentIMP:UniProtKB
Mitotic nuclear membrane reassemblyManual Assertion Based On ExperimentIDA:FlyBase
Negative regulation of cell population proliferationManual Assertion Based On ExperimentIMP:FlyBase
Negative regulation of immune responseManual Assertion Based On ExperimentIMP:FlyBase
Nuclear envelope organizationManual Assertion Based On ExperimentIMP:FlyBase
Nuclear membrane organizationManual Assertion Based On ExperimentIDA:FlyBase
Nuclear migrationManual Assertion Based On ExperimentIMP:FlyBase
Nuclear pore localizationManual Assertion Based On ExperimentIMP:FlyBase
Nucleus organizationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of actin filament polymerizationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of cytokinesis, actomyosin contractile ring assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of protein localization to nucleusManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of spindle assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Protein localization to nuclear envelopeManual Assertion Based On ExperimentIMP:FlyBase
Spermatocyte divisionManual Assertion Based On ExperimentIMP:UniProtKB
SpermatogenesisManual Assertion Based On ExperimentIMP:FlyBase
Terminal branching, open tracheal systemManual Assertion Based On ExperimentIMP:FlyBase
Cellular Location
Nucleus
Nucleus inner membrane
Nucleus envelope
Nucleus lamina
Cytoplasm, cytoskeleton, spindle pole
Cytoplasm
Nuclear periphery (PubMed:7593280).
At metaphase and anaphase, weakly expressed in the nuclear envelope and spindle poles (PubMed:16439308).
Expression in oocyte cytoplasm increases after stages 6 to 7 of egg development (PubMed:9199347).
In spermatocytes detected at the spindle envelope, spindle poles and astral membrane throughout meiosis I, whereas mostly depleted in meiosis II (PubMed:27402967).
Colocalizes with nuclear pore complex component Nup107 throughout meiosis I (PubMed:27402967).4 Publications
PTM
Three forms of lamin have been identified in D.melanogaster, lamin Dm0 is rapidly processed to lamin Dm1 in the cytoplasm, Dm1 is then assembled in the nuclear envelope and is then phosphorylated, forming lamin Dm2.

Anti-LAM antibodies

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Target: LAM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Common fruit fly
Clone: ADL40
Application*: WB
Target: LAM
Host: Mouse
Antibody Isotype: IgM
Specificity: Common fruit fly
Clone: ADL195
Application*: IF, WB
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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