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Mouse Anti-LAM Recombinant Antibody (ADL40) (CBMAB-0346-CN)


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Summary

Host Animal
Mouse
Specificity
Common fruit fly
Clone
ADL40
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Recombinant total protein of lamin
Specificity
Common fruit fly
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Lam
Introduction
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. This protein may have a role in the localization of the LEM domain proteins Ote, bocks and MAN1 to the nuclear membrane. In spermatocytes, plays a role in maintaining type-A lamin LamC nuclear localization; regulates meiotic cytokinesis by maintaining the structure of the spindle envelope, and by contributing to the formation of the contractile ring and central spindle.
Entrez Gene ID
33782
UniProt ID
P08928
Alternative Names
2459; 74/76; CG6944; D5; Dm; Dm(0); Dm0; Dm1; Dm2; Dmel\CG6944; DmLamin; Dmo; DmO; Dm[[0]]; Dm[[1]]; Dm[[2]]; Dm[[mit]]; Dm[[o]]; DM[[O]]; D[[m0]]; jf27; l(2)04643; l(2)25Ec; l(2)gdh-7; l(2)gdh7; l(2)jf27; lam; LAM; Lam Dm[[0]]; Lam(Dm0); LamDm; lamDm0; LamDm0; lamDm[[0]]; LamDm[[0]]; LamDm[[o]]; lamin; lamin B; Lamin B; lamin Dm0; lamin Dm[[0]]; Lamin Dm[[0]]; lamin-B; Lam[[Dm0]]; misg; nlam
Function
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin (PubMed:3126192, PubMed:15035436).
May have a role in the localization of the LEM domain proteins Ote, bocks and MAN1 to the nuclear membrane (PubMed:15035436, PubMed:16439308).
In spermatocytes, plays a role in maintaining type-A lamin LamC nuclear localization; regulates meiotic cytokinesis by maintaining the structure of the spindle envelope, and by contributing to the formation of the contractile ring and central spindle (PubMed:27402967).
Required for nuclear migration and to link the microtubule organizing center (MTOC) to the nucleus (PubMed:14617811).
In addition, is required for nuclear envelope localization of klar (PubMed:14617811).
Biological Process
Adult locomotory behaviorManual Assertion Based On ExperimentIMP:FlyBase
Cell agingManual Assertion Based On ExperimentIMP:FlyBase
Central nervous system developmentManual Assertion Based On ExperimentIMP:FlyBase
Chitin-based cuticle developmentManual Assertion Based On ExperimentIMP:FlyBase
Compound eye morphogenesisManual Assertion Based On ExperimentIMP:FlyBase
Digestive tract morphogenesisManual Assertion Based On ExperimentIMP:FlyBase
Gonad morphogenesisManual Assertion Based On ExperimentIMP:FlyBase
Heterochromatin assemblyManual Assertion Based On ExperimentIDA:FlyBase
Heterochromatin organizationManual Assertion Based On ExperimentIMP:FlyBase
Male meiosis cytokinesisManual Assertion Based On ExperimentIMP:UniProtKB
Meiosis I cytokinesisManual Assertion Based On ExperimentIMP:UniProtKB
Mitotic nuclear membrane reassemblyManual Assertion Based On ExperimentIDA:FlyBase
Negative regulation of cell population proliferationManual Assertion Based On ExperimentIMP:FlyBase
Negative regulation of immune responseManual Assertion Based On ExperimentIMP:FlyBase
Nuclear envelope organizationManual Assertion Based On ExperimentIMP:FlyBase
Nuclear membrane organizationManual Assertion Based On ExperimentIDA:FlyBase
Nuclear migrationManual Assertion Based On ExperimentIMP:FlyBase
Nuclear pore localizationManual Assertion Based On ExperimentIMP:FlyBase
Nucleus organizationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of actin filament polymerizationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of cytokinesis, actomyosin contractile ring assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of protein localization to nucleusManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of spindle assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Protein localization to nuclear envelopeManual Assertion Based On ExperimentIMP:FlyBase
Spermatocyte divisionManual Assertion Based On ExperimentIMP:UniProtKB
SpermatogenesisManual Assertion Based On ExperimentIMP:FlyBase
Terminal branching, open tracheal systemManual Assertion Based On ExperimentIMP:FlyBase
Cellular Location
Nucleus
Nucleus inner membrane
Nucleus envelope
Nucleus lamina
Cytoplasm, cytoskeleton, spindle pole
Cytoplasm
Nuclear periphery (PubMed:7593280).
At metaphase and anaphase, weakly expressed in the nuclear envelope and spindle poles (PubMed:16439308).
Expression in oocyte cytoplasm increases after stages 6 to 7 of egg development (PubMed:9199347).
In spermatocytes detected at the spindle envelope, spindle poles and astral membrane throughout meiosis I, whereas mostly depleted in meiosis II (PubMed:27402967).
Colocalizes with nuclear pore complex component Nup107 throughout meiosis I (PubMed:27402967).4 Publications
PTM
Three forms of lamin have been identified in D.melanogaster, lamin Dm0 is rapidly processed to lamin Dm1 in the cytoplasm, Dm1 is then assembled in the nuclear envelope and is then phosphorylated, forming lamin Dm2.
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For research use only. Not intended for any clinical use.

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