L1RE1

Nucleic acid-binding protein which is necessary for retrotransposition of LINE-1 elements in the genome. L1RE1 functions as a nucleic acid chaperone binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded.

Full Name

Line-1 Retrotransposable Element Orf1 Protein

Function

Nucleic acid-binding protein which is essential for retrotransposition of LINE-1 elements in the genome. Functions as a nucleic acid chaperone binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded.

Biological Process

Transposition, RNA-mediatedManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Nucleus, nucleolus
Cytoplasm, Cytoplasmic ribonucleoprotein granule
Cytoplasm, Stress granule
Colocalizes with its encoding RNA in cytoplasmic ribonucleoprotein particle (PubMed:16183655).
Mainly cytoplasmic, rarely detected in the nucleus, possibly within the nucleolus (PubMed:17562864).

PTM

Polyubiquitinated, probably by UBR2, which induces its degradation.

Anti-L1RE1 antibodies

Rabbit Anti-L1RE1 Recombinant Antibody (CBYJL-1031) (CBMAB-L0443-YJ)

Datasheet

SDS

Target: L1RE1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJL-1031

Application*: WB

Rabbit Anti-L1RE1 Recombinant Antibody (D3W9O) (CBMAB-CP1327-LY)

Datasheet

SDS

Target: L1RE1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: D3W9O

Application*: WB

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)