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Rabbit Anti-L1RE1 Recombinant Antibody (CBYJL-1031) (CBMAB-L0443-YJ)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBYJL-1031
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Line-1 Retrotransposable Element Orf1 Protein
Introduction
Nucleic acid-binding protein which is necessary for retrotransposition of LINE-1 elements in the genome. L1RE1 functions as a nucleic acid chaperone binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded.
UniProt ID
Q9UN81
Alternative Names
L1RE1; LRE1
Function
Nucleic acid-binding protein which is essential for retrotransposition of LINE-1 elements in the genome. Functions as a nucleic acid chaperone binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded.
Biological Process
Transposition, RNA-mediatedManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus, nucleolus
Cytoplasm, Cytoplasmic ribonucleoprotein granule
Cytoplasm, Stress granule
Colocalizes with its encoding RNA in cytoplasmic ribonucleoprotein particle (PubMed:16183655).
Mainly cytoplasmic, rarely detected in the nucleus, possibly within the nucleolus (PubMed:17562864).
PTM
Polyubiquitinated, probably by UBR2, which induces its degradation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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