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Krt8

This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene.
Full Name
Keratin 8
Alternative Names
Keratin 8; Type-II Keratin Kb8; Keratin 8, Type II; Cytokeratin-8; CK-8; CYK8; K8;
Function
Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
Cellular Location
Cytoplasm 2 Publications
Nucleus, nucleoplasm By Similarity
Nucleus matrix
Involvement in disease
Cirrhosis (CIRRH):
A liver disease characterized by severe panlobular liver-cell swelling with Mallory body formation, prominent pericellular fibrosis, and marked deposits of copper. Clinical features include abdomen swelling, jaundice and pulmonary hypertension.
PTM
Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization.
O-glycosylated. O-GlcNAcylation at multiple sites increases solubility, and decreases stability by inducing proteasomal degradation.
O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.

Anti-Krt8 antibodies

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Target: KRT8
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EC122
Application*: WB, P
Target: KRT8
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A848
Application*: ELISA, IHC, WB
Target: KRT8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A847
Application*: IF, IHC, WB
Target: KRT8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Hamster, Human, Mouse, Rat
Clone: A846
Application*: ICC, IF, IHC, WB
Target: KRT8
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: A845
Application*: Dot blot, ELISA, WB
Target: KRT8
Host: Mouse
Antibody Isotype: IgM
Specificity: Human, Zebrafish
Clone: 35_H11
Application*: IHC, IP, WB
Target: KRT8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CF264
Application*: ELISA, WB, IHC
Target: KRT8
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CB366A
Application*: ELISA, WB, IHC
Target: KRT8
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CB43A
Application*: ELISA, IHC
Target: KRT8
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CB303
Application*: WB, IHC
Target: KRT8
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: 3G9
Application*: FC, IHC-P, IHC-F, WB
Target: KRT8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Dog, Chicken, Guinea pig, Hamster, Human, Pig, Rabbit, Rat
Clone: RCK
Application*: WB, IH, IC, F
Target: KRT8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: RCK106
Application*: Dot, F
Target: KRT8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Zebrafish, Dog, Pig
Clone: RKSE60
Application*: WB, C
Target: KRT8
Host: Mouse
Antibody Isotype: IgM
Specificity: Human, Zebrafish
Clone: CBCNC-650
Application*: WB, P, C
Target: KRT8
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: 35bH11
Application*: IH, WB
Target: KRT8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Chicken, Horse, Rat, Frog
Clone: CBWJC-4103
Application*: C, P
Target: KRT8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJC-4102
Application*: C, WB
Target: KRT8
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human, Monkey, Rabbit
Clone: CBWJC-4101
Application*: F, IF, P
Target: KRT8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJC-4100
Application*: F, IF, P
Target: KRT8
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBWJC-4098
Application*: P
Target: KRT8
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJC-4094
Application*: WB, P, IC, F, IC
Target: KRT8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-4091
Application*: IH
Target: KRT8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJC-4088
Application*: IH, P
Target: KRT8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJC-4087
Application*: P
Target: KRT8
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CBWJC-4086
Application*: E, WB
Target: KRT8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Chicken, Human, Mouse, Rabbit, Rat
Clone: CBWJC-4084
Application*: IC, IF, P, WB
Target: KRT8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBWJC-4083
Application*: WB, P, IC, F
Target: KRT8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Hamster, Human, Mouse, Rat
Clone: Ks8.7
Application*: C, P, WB
Target: KRT8
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: KRT8/803 + KRT18/835
Application*: WB, F, P, IF
Target: KRT8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJC-2314
Application*: WB, F, IC, P
Target: KRT8
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: K8.8 + DC10
Application*: WB, F, IC, IP, P, C
Target: KRT8
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Human
Clone: CBWJC-2313
Application*: WB, IP, P, F, IC
Target: KRT8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-2311
Application*: P, C, IC
Target: KRT8
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: C-43 + DC10
Application*: WB, F, P, IF, MC
Target: KRT8
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Cattle, Chicken, Rabbit
Clone: CBWJC-2310
Application*: WB, IH, P, C
Target: KRT8
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBYY-C3095
Application*: WB, IH
Target: KRT8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rabbit, Rat
Clone: CBXC-0670
Application*: F, IC, C, P, WB
Target: KRT8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-3079
Application*: WB, E, IH, IF, P, C
Target: KRT8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2272
Application*: IH, P
Target: KRT8
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXC-1920
Application*: WB, IH, IF, P
Target: KRT8
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: RM266
Application*: WB, IH
Target: KRT8
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0937
Application*: F
Target: KRT8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Zebrafish
Clone: SPM538
Application*: WB, F, IF, IP, P, C
Target: KRT8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: LP3K
Application*: WB
Target: KRT8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Pig, Monkey, Sheep
Clone: C-51
Application*: WB, F, P, IF
Target: KRT8
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Cattle, Chicken, Rabbit
Clone: AE3
Application*: WB, P, C
Target: KRT8
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: CBXC-2173
Application*: WB, E
Target: KRT8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBYY-C2627
Application*: IH, WB
Target: KRT8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-C2626
Application*: IF, IH, P, WB
Target: KRT8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2625
Application*: F, IC, IH, WB
Target: KRT8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-C2624
Application*: IH
Target: KRT8
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: 3D11
Application*: WB, E
Target: KRT8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Cattle, Human
Clone: CBFYC-2911
Application*: WB, P, IF
Target: KRT8
Host: Mouse
Antibody Isotype: IgG2a, λ
Specificity: Human, Mouse, Dog
Clone: CBFYC-2910
Application*: P, IF, WB
Target: KRT8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYC-2909
Application*: IF, WB
Target: KRT8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-2908
Application*: E, IH, WB
Target: KRT8
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Human, Rat
Clone: 8G8
Application*: IH
Target: KRT8
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 5K3
Application*: WB, IH
Target: KRT8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4A41
Application*: F, IC, C, WB
Target: KRT8
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: 35946;H11
Application*: P, WB
Target: KRT8
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: 35223;E11
Application*: P, C
Target: KRT8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2Q1128
Application*: IC, C, WB
Target: KRT8
Host: Mouse
Antibody Isotype: IgG2a, λ
Specificity: Human, Mouse, Dog
Clone: 1E8
Application*: P, IF, WB
Target: KRT8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13B215
Application*: E, C, WB
Target: KRT8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Zebrafish
Clone: H1
Application*: F, IC, C, P, WB
Target: KRT8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rat, Rabbit, Cattle, Chicken, Pig, Sheep, Frog
Clone: B22.1
Application*: P, IF/IC, F
Target: KRT8
Host: Mouse
Antibody Isotype: IgM
Specificity: Human, Zebrafish
Clone: 35betaH11
Application*: C, P, WB
Target: KRT8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: UMAB1
Application*: WB, IH, IF
Target: KRT8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: TS1
Application*: P
Target: KRT8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: SPM192
Application*: P, IF/IC, F
Target: KRT8
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: SP102
Application*: P
Target: KRT8
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: R15-K
Application*: P, C
Target: KRT8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: NCL5D3
Application*: C, P, WB
Target: KRT8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: Ks8-7
Application*: C, P, WB
Target: KRT8
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human, Rabbit, Monkey
Clone: KRT8/899
Application*: P, IF/IC, F
Target: KRT8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: KRT8/803
Application*: P, IF/IC, F
Target: KRT8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: H1-TS1
Application*: F
Target: KRT8
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: EP1628Y
Application*: WB, IP, F, P, IC/IF
Target: KRT8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CK207
Application*: IF, C, P
Target: KRT8
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: AT3D11
Application*: E, IA, WB
Target: KRT8
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: AH9R7
Application*: E, IC, IF, WB
Target: KRT8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8A5D12
Application*: E, IA, IF, P, WB
Target: KRT8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Dog, Monkey
Clone: 4D12
Application*: IF, IH, WB
Target: KRT8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4C5-E10-E6
Application*: E
Target: KRT8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4A42
Application*: IH
Target: KRT8
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3E3
Application*: E, IF, WB
Target: KRT8
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 2F5
Application*: IH
Target: KRT8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2E4
Application*: IF, IH, WB
Target: KRT8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2A4
Application*: C, WB
Target: KRT8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1B9
Application*: IF, WB
Target: KRT8
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Dog, Rat, Monkey
Clone: 1B12
Application*: IF, IH, WB
Target: KRT8
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Cattle, Hamster, Rat
Clone: 16k211
Application*: IH, WB
Target: KRT8
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 15B36
Application*: E, WB
Target: KRT8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 0.N.351
Application*: E, IH, IP
Target: KRT8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLY1-157
Application*: WB, IH
Target: KRT8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: SB37b
Application*: E, IC, IH, WB
Target: KRT8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: C-43
Application*: F
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
Online Inquiry