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KRT14

This gene encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex. At least one pseudogene has been identified at 17p12-p11. [provided by RefSeq, Jul 2008]
Full Name
Keratin 14
Function
The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro.
Biological Process
AgingManual Assertion Based On ExperimentIDA:UniProtKB
Epidermis developmentManual Assertion Based On ExperimentTAS:ProtInc
Epithelial cell differentiationIEA:Ensembl
Hair cycleManual Assertion Based On ExperimentIDA:UniProtKB
Intermediate filament bundle assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytoplasm
Nucleus
Expressed in both as a filamentous pattern.
Involvement in disease
Epidermolysis bullosa simplex, Dowling-Meara type (DM-EBS):
A severe form of intraepidermal epidermolysis bullosa characterized by generalized herpetiform blistering, milia formation, dystrophic nails, and mucous membrane involvement.
Epidermolysis bullosa simplex, Weber-Cockayne type (WC-EBS):
A form of intraepidermal epidermolysis bullosa characterized by blistering limited to palmar and plantar areas of the skin.
Epidermolysis bullosa simplex, Koebner type (K-EBS):
A form of intraepidermal epidermolysis bullosa characterized by generalized skin blistering. The phenotype is not fundamentally distinct from the Dowling-Meara type, although it is less severe.
Epidermolysis bullosa simplex, autosomal recessive 1 (EBSB1):
A form of epidermolysis bullosa, a genodermatosis characterized by recurrent blistering and cleavage within basal keratinocytes, fragility of the skin and mucosal epithelia, and erosions caused by minor mechanical trauma.
Naegeli-Franceschetti-Jadassohn syndrome (NFJS):
A rare autosomal dominant form of ectodermal dysplasia. The cardinal features are absence of dermatoglyphics (fingerprints), reticular cutaneous hyperpigmentation (starting at about the age of 2 years without a preceding inflammatory stage), palmoplantar keratoderma, hypohidrosis with diminished sweat gland function and discomfort provoked by heat, nail dystrophy, and tooth enamel defects.
Dermatopathia pigmentosa reticularis (DPR):
A rare ectodermal dysplasia characterized by lifelong persistent reticulate hyperpigmentation, non-cicatricial alopecia, and nail dystrophy. Variable features include adermatoglyphia, hypohidrosis or hyperhidrosis, and palmoplantar hyperkeratosis.
PTM
A disulfide bond is formed between rather than within filaments and promotes the formation of a keratin filament cage around the nucleus.
Ubiquitinated by the BCR(KLHL24) E3 ubiquitin ligase complex.

Anti-KRT14 antibodies

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Target: KRT14
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human, Mouse, Pig
Clone: A787
Application*: FC, IF, IHC, WB
Target: KRT14
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Pig
Clone: A786
Application*: IF, IHC, IP, WB
Target: KRT14
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human, Mouse, Rat
Clone: LL002
Application*: FC, IF, IHC
Target: KRT14
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 21
Application*: ELISA, IF, IHC, WB
Target: KRT14
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 4H1
Application*: IHC
Target: KRT14
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: PT0078
Application*: IHC
Target: KRT14
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CF259
Application*: ELISA, WB, IHC, IF
Target: KRT14
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CB115A
Application*: ELISA, IHC
Target: KRT14
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CB44A
Application*: ELISA, IHC
Target: KRT14
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: RM328
Application*: IHC, WB
Target: KRT14
Host: Mouse
Specificity: Human
Clone: IHC555
Application*: IH
Target: KRT14
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human, Rat
Clone: CBCNC-624
Application*: WB, P
Target: KRT14
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJC-3995
Application*: WB, IC
Target: KRT14
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Rat, Cat
Clone: CBWJC-3994
Application*: F, IF
Target: KRT14
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBWJC-3993
Application*: C, WB, P
Target: KRT14
Host: Mouse
Antibody Isotype: IgM
Specificity: Rat, Sheep, Goat, Human
Clone: CBWJC-3992
Application*: WB, P, C, IC
Target: KRT14
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat, Rabbit, Chicken, Cattle, Human, Monkey
Clone: CBWJC-3990
Application*: P, IC
Target: KRT14
Host: Mouse
Antibody Isotype: IgG1
Specificity: Goat, Chicken, Cattle, Dog, Human, Pig, Mouse
Clone: CBWJC-3989
Application*: P
Target: KRT14
Host: Human
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJC-3988
Application*: P, E, WB
Target: KRT14
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human, Mouse, Rat
Clone: CBWJC-2275
Application*: F, P, IF, MC
Target: KRT14
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBWJC-2274
Application*: WB, P, IC
Target: KRT14
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJC-2273
Application*: IC, IH, P, WB
Target: KRT14
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJC-2272
Application*: WB, IP, P, F, IC
Target: KRT14
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat, Cattle, Human
Clone: CBWJC-2271
Application*: WB, P, C, DB, IC
Target: KRT14
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human, Mouse, Pig
Clone: LL002
Application*: F, IH, IF, WB
Target: KRT14
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Pig
Clone: LL001
Application*: IH, IF, IP, WB
Target: KRT14
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: 2Q1030
Application*: IH
Target: KRT14
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human, Rat
Clone: CBXC-0664
Application*: P, WB
Target: KRT14
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXC-2895
Application*: WB, IH
Target: KRT14
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXC-2411
Application*: WB, F, E
Target: KRT14
Host: Mouse
Antibody Isotype: IgG1
Specificity: Dog, Human, Pig
Clone: CBYY-C2823
Application*: IF, IH, WB
Target: KRT14
Host: Mouse
Antibody Isotype: IgG3
Specificity: Dog, Human, Pig, Rat
Clone: CBYY-C2822
Application*: F, IC, IH, WB
Target: KRT14
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human, Rat
Clone: CBFYC-2880
Application*: P, WB
Target: KRT14
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYC-0279
Application*: WB, F, E
Target: KRT14
Host: Mouse
Antibody Isotype: IgG1
Specificity: Dog, Human, Pig
Clone: 5F298
Application*: IF, C, WB
Target: KRT14
Host: Mouse
Antibody Isotype: IgG3
Specificity: Dog, Human, Pig, Rat
Clone: 4A30
Application*: F, IC, C, WB
Target: KRT14
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 13F4
Application*: WB, F, E
Target: KRT14
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 2G1E2
Application*: E, WB, IH, IF
Target: KRT14
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human, Rat
Clone: SPM263
Application*: P, IF/IC, F
Target: KRT14
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: SPK-14
Application*: F, IC, C, WB
Target: KRT14
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: SP53
Application*: F, P, WB
Target: KRT14
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: RCK107
Application*: C, WB
Target: KRT14
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human, Rat
Clone: KRT14/532
Application*: P, IF/IC, F
Target: KRT14
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Rat, Cat
Clone: KRT14/284
Application*: IF/IC, F
Target: KRT14
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: DE-SPK14
Application*: IH
Target: KRT14
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D19-N
Application*: P, C
Target: KRT14
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CTKN14-1
Application*: IF, P
Target: KRT14
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: AT13F4
Application*: IA, WB
Target: KRT14
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 4A7
Application*: WB
Target: KRT14
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: 3H2053
Application*: F, IF, IH, WB
Target: KRT14
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human, Rat
Clone: 0.N.359
Application*: IH, WB
Target: KRT14
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CBYY-C0166
Application*: IH, WB, F
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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