Mouse Anti-KRT14 Recombinant Antibody (CBYY-C2823) (CBMAB-C4264-YY)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Dog, Human, Pig

Clone

CBYY-C2823

Antibody Isotype

IgG1

Application

IF, IHC, WB

Basic Information

Immunogen

Isolated from TR146 cells (human tumor cell line)

Specificity

Dog, Human, Pig

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Culture supernatant

Concentration

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Keratin 14

Entrez Gene ID

Human	3861
Dog	100685323
Pig	100737113

UniProt ID

Human	P02533
Dog	F1Q0R0
Pig	F1S0J8

Alternative Names

CREB; CREB-1

Function

The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro.

Biological Process

AgingManual Assertion Based On ExperimentIDA:UniProtKB
Epidermis developmentManual Assertion Based On ExperimentTAS:ProtInc
Epithelial cell differentiationIEA:Ensembl
Hair cycleManual Assertion Based On ExperimentIDA:UniProtKB
Intermediate filament bundle assemblyManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cytoplasm
Nucleus
Expressed in both as a filamentous pattern.

Involvement in disease

Epidermolysis bullosa simplex, Dowling-Meara type (DM-EBS):
A severe form of intraepidermal epidermolysis bullosa characterized by generalized herpetiform blistering, milia formation, dystrophic nails, and mucous membrane involvement.
Epidermolysis bullosa simplex, Weber-Cockayne type (WC-EBS):
A form of intraepidermal epidermolysis bullosa characterized by blistering limited to palmar and plantar areas of the skin.
Epidermolysis bullosa simplex, Koebner type (K-EBS):
A form of intraepidermal epidermolysis bullosa characterized by generalized skin blistering. The phenotype is not fundamentally distinct from the Dowling-Meara type, although it is less severe.
Epidermolysis bullosa simplex, autosomal recessive 1 (EBSB1):
A form of epidermolysis bullosa, a genodermatosis characterized by recurrent blistering and cleavage within basal keratinocytes, fragility of the skin and mucosal epithelia, and erosions caused by minor mechanical trauma.
Naegeli-Franceschetti-Jadassohn syndrome (NFJS):
A rare autosomal dominant form of ectodermal dysplasia. The cardinal features are absence of dermatoglyphics (fingerprints), reticular cutaneous hyperpigmentation (starting at about the age of 2 years without a preceding inflammatory stage), palmoplantar keratoderma, hypohidrosis with diminished sweat gland function and discomfort provoked by heat, nail dystrophy, and tooth enamel defects.
Dermatopathia pigmentosa reticularis (DPR):
A rare ectodermal dysplasia characterized by lifelong persistent reticulate hyperpigmentation, non-cicatricial alopecia, and nail dystrophy. Variable features include adermatoglyphia, hypohidrosis or hyperhidrosis, and palmoplantar hyperkeratosis.

PTM

A disulfide bond is formed between rather than within filaments and promotes the formation of a keratin filament cage around the nucleus.
Ubiquitinated by the BCR(KLHL24) E3 ubiquitin ligase complex.

More Infomation

References

Ievlev, V., Lynch, T. J., Freischlag, K. W., Gries, C. B., Shah, A., Pai, A. C., ... & Parekh, K. R. (2023). Krt14 and Krt15 differentially regulate regenerative properties and differentiation potential of airway basal cells. JCI insight, 8(2).

Guo, Y., Redmond, C. J., Leacock, K. A., Brovkina, M. V., Ji, S., Jaskula-Ranga, V., & Coulombe, P. A. (2020). Keratin 14-dependent disulfides regulate epidermal homeostasis and barrier function via 14-3-3σ and YAP1. Elife, 9, e53165.

Dong, Y., Li, S., Sun, X., Wang, Y., Lu, T., Wo, Y., ... & Jiao, W. (2020). Desmoglein 3 and keratin 14 for distinguishing between lung adenocarcinoma and lung squamous cell carcinoma. OncoTargets and therapy, 11111-11124.

Bilandzic, M., Rainczuk, A., Green, E., Fairweather, N., Jobling, T. W., Plebanski, M., & Stephens, A. N. (2019). Keratin-14 (KRT14) positive leader cells mediate mesothelial clearance and invasion by ovarian cancer cells. Cancers, 11(9), 1228.

Sümer, C., Er, A. B. B., & Dinçer, T. U. B. A. (2019). Keratin 14 is a novel interaction partner of keratinocyte differentiation regulator: receptor-interacting protein kinase 4. Turkish Journal of Biology, 43(4), 225-234.

Chin, I. K. N., Cheung, G. H. Y., Kwok, H. Y. Y., Ma, V. W. S., Lau, E. Y. T., & Cho, W. C. S. (2018). The novel function of keratin 14 (KRT14) in regulating cancer stem cell properties in lung adenocarcinoma. Cancer Research, 78(13_Supplement), 3067-3067.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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