KMO

This gene encodes a mitochondrion outer membrane protein that catalyzes the hydroxylation of L-tryptophan metabolite, L-kynurenine, to form L-3-hydroxykynurenine. Studies in yeast identified this gene as a therapeutic target for Huntington disease. [provided by RefSeq, Oct 2011]

Kynurenine 3-Monooxygenase

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn) (PubMed:29429898, PubMed:23575632, PubMed:26752518, PubMed:28604669, PubMed:29208702).
Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract (Probable)

de novo' NAD biosynthetic process from tryptophanIEA:UniProtKB-UniRule
AgingIEA:Ensembl
Anthranilate metabolic processIEA:UniProtKB-UniRule
Cellular response to interleukin-1IEA:Ensembl
Cellular response to lipopolysaccharideIEA:Ensembl
Kynurenic acid biosynthetic processIEA:Ensembl
Kynurenine metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
L-kynurenine metabolic processIEA:Ensembl
NAD metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of glutamate secretion, neurotransmissionIEA:Ensembl
Positive regulation of neuron deathIEA:Ensembl
Quinolinate biosynthetic processIEA:UniProtKB-UniRule
Response to salt stressManual Assertion Based On ExperimentIDA:UniProtKB
Tryptophan catabolic processTAS:Reactome

Mitochondrion outer membrane