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Mouse Anti-KMO Recombinant Antibody (A778) (CBMAB-AP11225LY)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
A778
Antibody Isotype
IgG1
Application
ELISA, IF, IHC, WB

Basic Information

Immunogen
Fusion protein of Kynurenine 3 monooxygenase
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
Affinity purity
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Kynurenine 3-Monooxygenase
Introduction
This gene encodes a mitochondrion outer membrane protein that catalyzes the hydroxylation of L-tryptophan metabolite, L-kynurenine, to form L-3-hydroxykynurenine. Studies in yeast identified this gene as a therapeutic target for Huntington disease. [provided by RefSeq, Oct 2011]
Entrez Gene ID
Human8564
Mouse98256
Rat59113
UniProt ID
HumanO15229
MouseQ91WN4
RatO88867
Alternative Names
Kynurenine 3-Monooxygenase; Kynurenine 3-Hydroxylase; EC 1.14.13.9; Kynurenine 3-Monooxygenase (Kynurenine 3-Hydroxylase); DJ317G22.1;
Function
Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn) (PubMed:29429898, PubMed:23575632, PubMed:26752518, PubMed:28604669, PubMed:29208702).
Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract (Probable)
Biological Process
de novo' NAD biosynthetic process from tryptophanIEA:UniProtKB-UniRule
AgingIEA:Ensembl
Anthranilate metabolic processIEA:UniProtKB-UniRule
Cellular response to interleukin-1IEA:Ensembl
Cellular response to lipopolysaccharideIEA:Ensembl
Kynurenic acid biosynthetic processIEA:Ensembl
Kynurenine metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
L-kynurenine metabolic processIEA:Ensembl
NAD metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of glutamate secretion, neurotransmissionIEA:Ensembl
Positive regulation of neuron deathIEA:Ensembl
Quinolinate biosynthetic processIEA:UniProtKB-UniRule
Response to salt stressManual Assertion Based On ExperimentIDA:UniProtKB
Tryptophan catabolic processTAS:Reactome
Cellular Location
Mitochondrion outer membrane
More Infomation

Sathyasaikumar, K. V., Pérez de la Cruz, V., Pineda, B., Vázquez Cervantes, G. I., Ramírez Ortega, D., Donley, D. W., ... & Schwarcz, R. (2022). Cellular localization of kynurenine 3-monooxygenase in the brain: Challenging the dogma. Antioxidants, 11(2), 315.

Chen, Y., Zhang, J., Yang, Y., Xiang, K., Li, H., Sun, D., & Chen, L. (2022). Kynurenine‐3‐monooxygenase (KMO): From its biological functions to therapeutic effect in diseases progression. Journal of Cellular Physiology, 237(12), 4339-4355.

Hughes, T. D., Güner, O. F., Iradukunda, E. C., Phillips, R. S., & Bowen, J. P. (2022). The kynurenine pathway and kynurenine 3-monooxygenase inhibitors. Molecules, 27(1), 273.

Zhao, J., Chen, J., Wang, C., Liu, Y., Li, M., Li, Y., ... & Sun, C. (2022). Kynurenine-3-monooxygenase (KMO) broadly inhibits viral infections via triggering NMDAR/Ca2+ influx and CaMKII/IRF3-mediated IFN-β production. PLoS Pathogens, 18(3), e1010366.

Liu, C. Y., Huang, T. T., Chen, J. L., Chu, P. Y., Lee, C. H., Lee, H. C., ... & Teng, H. W. (2021). Significance of kynurenine 3-monooxygenase expression in colorectal cancer. Frontiers in Oncology, 11, 620361.

Bondulich, M. K., Fan, Y., Song, Y., Giorgini, F., & Bates, G. P. (2021). Ablation of kynurenine 3-monooxygenase rescues plasma inflammatory cytokine levels in the R6/2 mouse model of Huntington’s disease. Scientific Reports, 11(1), 5484.

Lu, Y., Shao, M., & Wu, T. (2020). Kynurenine‐3‐monooxygenase: A new direction for the treatment in different diseases. Food Science & Nutrition, 8(2), 711-719.

Huang, T. T., Tseng, L. M., Chen, J. L., Chu, P. Y., Lee, C. H., Huang, C. T., ... & Liu, C. Y. (2020). Kynurenine 3-monooxygenase upregulates pluripotent genes through β-catenin and promotes triple-negative breast cancer progression. EBioMedicine, 54.

Zheng, X., Zhang, A., Binnie, M., McGuire, K., Webster, S. P., Hughes, J., ... & Mole, D. J. (2019). Kynurenine 3-monooxygenase is a critical regulator of renal ischemia–reperfusion injury. Experimental & Molecular Medicine, 51(2), 1-14.

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For research use only. Not intended for any clinical use.

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