KIF2C

This gene encodes a kinesin-like protein that functions as a microtubule-dependent molecular motor. The encoded protein can depolymerize microtubules at the plus end, thereby promoting mitotic chromosome segregation. Alternative splicing results in multiple transcript variants.

kinesin family member 2C

In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (PubMed:21820309).
Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis (PubMed:19060894).
Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment (PubMed:23891108).

Attachment of mitotic spindle microtubules to kinetochoreManual Assertion Based On ExperimentIMP:UniProtKB
Cell divisionIEA:UniProtKB-KW
Establishment or maintenance of microtubule cytoskeleton polarityManual Assertion Based On ExperimentIMP:HGNC-UCL
Metaphase plate congressionManual Assertion Based On ExperimentIMP:UniProtKB
Microtubule depolymerizationManual Assertion Based On ExperimentIDA:UniProtKB
Microtubule-based movementManual Assertion Based On ExperimentIBA:GO_Central
Mitotic metaphase plate congressionManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of chromosome segregationManual Assertion Based On ExperimentIMP:UniProtKB

Cytoplasm, cytoskeleton; Nucleus; Chromosome, centromere; Chromosome, centromere, kinetochore. Associates with the microtubule network at the growing distal tip (the plus-end) of microtubules, probably through interaction with MTUS2/TIP150 and MAPRE1 (By similarity).
Association with microtubule plus ends is also mediated by interaction with KIF18B. Centromeric localization requires the presence of BUB1 and SGO2.

Phosphorylation by AURKB, regulates association with centromeres and kinetochores and the microtubule depolymerization activity.
Ubiquitinated.