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Mouse Anti-KIF2C Recombinant Antibody (1G2) (CBMAB-K0876-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1G2
Antibody Isotype
IgG1, κ
Application
IF, WB

Basic Information

Immunogen
KIF2C (AAH14924, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
kinesin family member 2C
Introduction
This gene encodes a kinesin-like protein that functions as a microtubule-dependent molecular motor. The encoded protein can depolymerize microtubules at the plus end, thereby promoting mitotic chromosome segregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Entrez Gene ID
11004
UniProt ID
Q99661
Alternative Names
Kinesin Family Member 2C; Mitotic Centromere-Associated Kinesin; Kinesin-Like Protein 6; KNSL6; MCAK; Kinesin-Like 6 (Mitotic Centromere-Associated Kinesin); Testis Tissue Sperm-Binding Protein Li 68n; Kinesin-Like Protein KIF2C; CT139;
Function
In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (PubMed:21820309).
Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis (PubMed:19060894).
Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment (PubMed:23891108).
Biological Process
Attachment of mitotic spindle microtubules to kinetochoreManual Assertion Based On ExperimentIMP:UniProtKB
Cell divisionIEA:UniProtKB-KW
Establishment or maintenance of microtubule cytoskeleton polarityManual Assertion Based On ExperimentIMP:HGNC-UCL
Metaphase plate congressionManual Assertion Based On ExperimentIMP:UniProtKB
Microtubule depolymerizationManual Assertion Based On ExperimentIDA:UniProtKB
Microtubule-based movementManual Assertion Based On ExperimentIBA:GO_Central
Mitotic metaphase plate congressionManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of chromosome segregationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytoplasm, cytoskeleton; Nucleus; Chromosome, centromere; Chromosome, centromere, kinetochore. Associates with the microtubule network at the growing distal tip (the plus-end) of microtubules, probably through interaction with MTUS2/TIP150 and MAPRE1 (By similarity).
Association with microtubule plus ends is also mediated by interaction with KIF18B. Centromeric localization requires the presence of BUB1 and SGO2.
PTM
Phosphorylation by AURKB, regulates association with centromeres and kinetochores and the microtubule depolymerization activity.
Ubiquitinated.
More Infomation

Li, S., Ma, Y., Wu, C., & Hou, X. (2023). Knockdown of kinesin family member 2C restricts cell proliferation and induces cell cycle arrest in gastric cancer.

Zhang, B., Li, Y., Pang, X., & Wu, H. (2022). Bioinformatics analysis of kinesin family member 2C in human tumors: novel prognostic biomarker and tumor microenvironment regulator.

Yang, J., Wu, Z., Yang, L., Jeong, J. H., Zhu, Y., Lu, J., ... & Li, R. (2022). Characterization of kinesin family member 2C as a proto-oncogene in cervical cancer. Frontiers in Pharmacology, 12, 785981.

Zhang, B., Liu, P., Li, Y., Hu, Q., Li, H., Pang, X., & Wu, H. (2022). Multi-omics analysis of kinesin family member 2C in human tumors: novel prognostic biomarker and tumor microenvironment regulator. American Journal of Cancer Research, 12(11), 4954.

Mo, S., Fang, D., Zhao, S., Hoa, P. T. T., Zhou, C., Liang, T., ... & Han, C. (2022). Down regulated oncogene KIF2C inhibits growth, invasion, and metastasis of hepatocellular carcinoma through the Ras/MAPK signaling pathway and epithelial-to-mesenchymal transition. Annals of Translational Medicine, 10(3).

Ding, Q., Jiang, C., Zhou, Y., Duan, J., Lai, J., Jiang, M., & Lin, D. (2021). Kinesin family member 2C promotes hepatocellular carcinoma growth and metastasis via activating MEK/ERK pathway. Bioscience, Biotechnology, and Biochemistry, 85(11), 2241-2249.

Li, X., Huang, W., Huang, W., Wei, T., Zhu, W., Chen, G., & Zhang, J. (2020). Kinesin family members KIF2C/4A/10/11/14/18B/20A/23 predict poor prognosis and promote cell proliferation in hepatocellular carcinoma. American Journal of Translational Research, 12(5), 1614.

Zhu, S., Paydar, M., Wang, F., Li, Y., Wang, L., Barrette, B., ... & Peng, A. (2020). Kinesin Kif2C in regulation of DNA double strand break dynamics and repair. Elife, 9, e53402.

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For research use only. Not intended for any clinical use.

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