JUND

The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. This protein has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternative translation initiation site usage results in the production of different isoforms (PMID:12105216).

Full Name

JunD proto-oncogene, AP-1 transcription factor subunit

Function

Transcription factor binding AP-1 sites (PubMed:9989505).
Heterodimerizes with proteins of the FOS family to form an AP-1 transcription factor complex, thereby enhancing their DNA binding activity to an AP-1 consensus sequence 3'-TGA[GC]TCA-5' and enhancing their transcriptional activity (PubMed:9989505, PubMed:28981703).

Biological Process

AgingIEA:Ensembl
Cellular response to calcium ionIEA:Ensembl
Circadian rhythmIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:ComplexPortal
Osteoblast developmentIEA:Ensembl
Positive regulation of macrophage activationIEA:Ensembl
Positive regulation of osteoblast differentiationIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:CAFA
Regulation of cell cycleManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell population proliferationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Response to light stimulusIEA:Ensembl
Response to lipopolysaccharideIEA:Ensembl
Response to mechanical stimulusIEA:Ensembl
Response to organic cyclic compoundIEA:Ensembl
Response to peptide hormoneIEA:Ensembl
Transcription by RNA polymerase IIIEA:Ensembl

Cellular Location

Nucleus

PTM

Phosphorylated by MAP kinases MAPK8 and MAPK10; phosphorylation is inhibited in the presence of MEN1.