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Mouse Anti-JUND Recombinant Antibody (CBLXJ-046) (CBMAB-2204CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLXJ-046
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
Recombinant human JunD, aa47-156 P17535 (E. coli)
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 47-156

Target

Full Name
JunD proto-oncogene, AP-1 transcription factor subunit
Introduction
The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. This protein has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternative translation initiation site usage results in the production of different isoforms. Diseases associated with JUND include T-Cell Leukemia and Adult T-Cell Leukemia. Among its related pathways are Toll-like receptor signaling pathway and ERK Signaling. An important paralog of this gene is JUN.
Entrez Gene ID
3727
UniProt ID
P17535
Alternative Names
JUND; jun D proto-oncogene; transcription factor jun-D; activator protein 1; AP 1; JunD FL isoform; transcription factor jun D; JunD-FL isoform; AP-1
Function
Transcription factor binding AP-1 sites (PubMed:9989505).
Heterodimerizes with proteins of the FOS family to form an AP-1 transcription factor complex, thereby enhancing their DNA binding activity to an AP-1 consensus sequence 3'-TGA[GC]TCA-5' and enhancing their transcriptional activity (PubMed:9989505, PubMed:28981703).
Biological Process
AgingIEA:Ensembl
Cellular response to calcium ionIEA:Ensembl
Circadian rhythmIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:ComplexPortal
Osteoblast developmentIEA:Ensembl
Positive regulation of macrophage activationIEA:Ensembl
Positive regulation of osteoblast differentiationIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:CAFA
Regulation of cell cycleManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell population proliferationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Response to light stimulusIEA:Ensembl
Response to lipopolysaccharideIEA:Ensembl
Response to mechanical stimulusIEA:Ensembl
Response to organic cyclic compoundIEA:Ensembl
Response to peptide hormoneIEA:Ensembl
Transcription by RNA polymerase IIIEA:Ensembl
Cellular Location
Nucleus
PTM
Phosphorylated by MAP kinases MAPK8 and MAPK10; phosphorylation is inhibited in the presence of MEN1.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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