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IVNS1ABP

IVNS1ABP (Influenza Virus NS1A Binding Protein) is a Protein Coding gene. Diseases associated with IVNS1ABP include Influenza and Dengue Disease. Among its related pathways are Influenza A. An important paralog of this gene is KLHL26.
Full Name
IVNS1ABP
Function
Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats (By similarity).
Protects cells from cell death induced by actin destabilization (By similarity).
Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription (PubMed:16582008).
In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors (PubMed:25619834).
Inhibits pre-mRNA splicing (in vitro) (PubMed:9696811).
(Microbial infection) Involved in the alternative splicing of influenza A virus M1 mRNA through interaction with HNRNPK, thereby facilitating the generation of viral M2 protein.
Biological Process
Negative regulation of intrinsic apoptotic signaling pathwayIEA:Ensembl
Negative regulation of protein ubiquitinationManual Assertion Based On ExperimentIMP:UniProtKB
Response to virusManual Assertion Based On ExperimentIMP:UniProtKB
RNA splicingManual Assertion Based On ExperimentIMP:UniProtKB
Transcription by RNA polymerase IIIManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasm; Cytoplasm, cytoskeleton; Nucleus, nucleoplasm. Associated with actin filaments (By similarity).
Localization related to speckle domains which correspond to interchromatin granules and are enriched in factors involved in pre-mRNA splicing (PubMed:9696811).
Following influenza A virus infection, redistribution from speckles to a more diffuse distribution in the nucleoplasm (PubMed:9696811).
Involvement in disease
Immunodeficiency 70 (IMD70):
A primary immunodeficiency clinically characterized by human papillomavirus-associated warts on the hands, feet and face, recurrent bacterial infections, and autoinflammatory features, such as colitis, celiac disease, and retinal vasculitis. Immunologic workup shows decreased CD4+ T cells, decreased CD19+ B cells, and hypogammaglobulinemia. IMD70 inheritance is autosomal dominant with incomplete penetrance.

Anti-IVNS1ABP antibodies

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Target: IVNS1ABP
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4B1
Application*: WB, E
Target: IVNS1ABP
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1B10
Application*: E, IP, WB
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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