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Mouse Anti-IVNS1ABP Antibody (1B10) (CBMAB-0563-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1B10
Antibody Isotype
IgG2b
Application
ELISA, IP, WB

Basic Information

Immunogen
Recombinant protein
Specificity
Human
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
IVNS1ABP
Introduction
IVNS1ABP (influenza virus NS1A-binding protein) is a protein that in humans is encoded by the IVNS1ABP gene. IVNS1ABP gene expression may be regulated by MITF in melanocytic cells.
Entrez Gene ID
10625
UniProt ID
Q9Y6Y0
Alternative Names
HSPC068; KIAA0850; KLHL39; ND1; NS-1; NS1-BP
Function
Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats (By similarity).
Protects cells from cell death induced by actin destabilization (By similarity).
Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription (PubMed:16582008).
In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors (PubMed:25619834).
Inhibits pre-mRNA splicing (in vitro) (PubMed:9696811).
(Microbial infection) Involved in the alternative splicing of influenza A virus M1 mRNA through interaction with HNRNPK, thereby facilitating the generation of viral M2 protein.
Biological Process
Negative regulation of intrinsic apoptotic signaling pathwayIEA:Ensembl
Negative regulation of protein ubiquitinationManual Assertion Based On ExperimentIMP:UniProtKB
Response to virusManual Assertion Based On ExperimentIMP:UniProtKB
RNA splicingManual Assertion Based On ExperimentIMP:UniProtKB
Transcription by RNA polymerase IIIManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasm; Cytoplasm, cytoskeleton; Nucleus, nucleoplasm. Associated with actin filaments (By similarity).
Localization related to speckle domains which correspond to interchromatin granules and are enriched in factors involved in pre-mRNA splicing (PubMed:9696811).
Following influenza A virus infection, redistribution from speckles to a more diffuse distribution in the nucleoplasm (PubMed:9696811).
Involvement in disease
Immunodeficiency 70 (IMD70):
A primary immunodeficiency clinically characterized by human papillomavirus-associated warts on the hands, feet and face, recurrent bacterial infections, and autoinflammatory features, such as colitis, celiac disease, and retinal vasculitis. Immunologic workup shows decreased CD4+ T cells, decreased CD19+ B cells, and hypogammaglobulinemia. IMD70 inheritance is autosomal dominant with incomplete penetrance.
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For research use only. Not intended for any clinical use.

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