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ITGB2

This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants.
Full Name
integrin subunit beta 2
Alternative Names
LAD; CD18; MF17; MFI7; LCAMB; LFA-1; MAC-1
Function
Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (PubMed:29100055).
Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity (PubMed:15356110).
Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992, PubMed:28807980).
Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400).
Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).
In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407).
Biological Process
Aging Source: Ensembl
Amyloid-beta clearance Source: ARUK-UCL
Apoptotic process Source: UniProtKB
Cell adhesion Source: UniProtKB
Cell adhesion mediated by integrin Source: GO_Central
Cell-cell adhesion Source: BHF-UCL
Cell-cell adhesion via plasma-membrane adhesion molecules Source: ARUK-UCL
Cell-cell signaling Source: UniProtKB
Cell-matrix adhesion Source: UniProtKB
Cell migration Source: GO_Central
Cellular extravasation Source: Ensembl
Cellular response to low-density lipoprotein particle stimulus Source: UniProtKB
Cytokine-mediated signaling pathway Source: Reactome
Endodermal cell differentiation Source: UniProtKB
Endothelial cell migration Source: Ensembl
Extracellular matrix organization Source: Reactome
Heterotypic cell-cell adhesion Source: UniProtKB
Inflammatory response Source: UniProtKB
Integrin-mediated signaling pathway Source: UniProtKB
Leukocyte cell-cell adhesion Source: UniProtKB
Leukocyte migration Source: Reactome
Leukocyte migration involved in inflammatory response Source: Ensembl
Microglial cell activation Source: ARUK-UCL
Natural killer cell activation Source: Ensembl
Negative regulation of dopamine metabolic process Source: ARUK-UCL
Neutrophil chemotaxis Source: UniProtKB
Neutrophil degranulation Source: Reactome
Neutrophil migration Source: UniProtKB
Phagocytosis, engulfment Source: ARUK-UCL
Positive regulation of angiogenesis Source: Ensembl
Positive regulation of leukocyte adhesion to vascular endothelial cell Source: UniProtKB
Positive regulation of neuron death Source: ARUK-UCL
Positive regulation of neutrophil degranulation Source: UniProtKB
Positive regulation of NF-kappaB transcription factor activity Source: Ensembl
Positive regulation of nitric oxide biosynthetic process Source: Ensembl
Positive regulation of prostaglandin-E synthase activity Source: ARUK-UCL
Positive regulation of protein targeting to membrane Source: ARUK-UCL
Positive regulation of superoxide anion generation Source: UniProtKB
Receptor clustering Source: UniProtKB
Receptor internalization Source: UniProtKB
Receptor-mediated endocytosis Source: ARUK-UCL
Regulation of cell shape Source: UniProtKB
Regulation of immune response Source: Reactome
Regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
Toll-like receptor 4 signaling pathway Source: Reactome
Cellular Location
Cell membrane; Membrane raft
Involvement in disease
Leukocyte adhesion deficiency 1 (LAD1): LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions.
Topology
Extracellular: 23-700
Helical: 701-723
Cytoplasmic: 724-769
PTM
Both Ser-745 and Ser-756 become phosphorylated when T-cells are exposed to phorbol esters (PubMed:11700305). Phosphorylation on Thr-758 (but not on Ser-756) allows interaction with 14-3-3 proteins (PubMed:11700305, PubMed:16301335).

Anti-ITGB2 antibodies

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Target: ITGB2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: AG124
Application*: F, IF, In Vivo
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A695
Application*: FC, IF
Target: ITGB2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: A694
Application*: FC, IHC, IP, WB
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Pig
Clone: BU87
Application*: IHC
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: BU86
Application*: FC, IHC
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: HI18a
Application*: FC
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB291
Application*: IF, FC
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB290
Application*: IF, FC
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB289
Application*: IF, FC
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBHb243
Application*: FC, IHC-F, FuncS, Immuno assays, IP
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBAb140
Application*: WB, IH, IP
Target: ITGB2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D4N5Z
Application*: WB
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3C7
Application*: WB, E
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: 2Q813
Application*: F
Target: ITGB2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: YTS 213.1
Application*: IP, F
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Rat, Human
Clone: TA-4
Application*: F
Target: ITGB2
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: MAB0816
Application*: B, S
Target: ITGB2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: YTS213.1
Application*: C, IP, F
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: R3.3
Application*: F
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: WT.3
Application*: F
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Pig
Clone: PNK/1
Application*: F
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CLB-LFA-1/1
Application*: FC
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2Q822
Application*: WB
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5F21
Application*: FC, IF
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3H1050
Application*: FC, IP, WB
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: IB4
Application*: IP
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Pig
Clone: BU87
Application*: IH
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: BU86
Application*: F, IH
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 24
Application*: F, IH, IF, IP, R, WB
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MEM-148
Application*: F, IP, WB, FN
Target: ITGB2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXC-1379
Application*: F, IH, IP
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rabbit
Clone: CBXC-1665
Application*: F, IH
Target: ITGB2
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBXC-1628
Application*: F, IH, IP, WB
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: TS1/18
Application*: F
Target: ITGB2
Host: Human
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBXC-0936
Application*: F
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rabbit
Clone: CBYY-C2776
Application*: F, IH
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2775
Application*: F, IH, IP, WB
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2774
Application*: F, IH, WB
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBYY-C2772
Application*: F, IP
Target: ITGB2
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBYY-C0441
Application*: F, IH, IP, WB
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0256
Application*: IF, F
Target: ITGB2
Host: Rat
Antibody Isotype: IgG2b
Specificity: Dog, Human
Clone: CBYY-C0091
Application*: F, IH, IP
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBYY-C0090
Application*: F, IH, IP
Target: ITGB2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYY-I1735
Application*: WB, IP
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Dog
Clone: CBYY-I1616
Application*: F, IF, C, IP
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 5F12
Application*: E, WB
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 534CT6.2.1
Application*: IH, WB, E, P
Target: ITGB2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYY-I0525
Application*: F, C, IP, WB
Target: ITGB2
Host: Rat
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-I0497
Application*: BL, F, FN, C, IP
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBYY-I0494
Application*: F, IC, C, WB
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0478
Application*: F
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Pig
Clone: CBYY-I0399
Application*: F, IP, FN
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0315
Application*: WB, F, IP, FN, MC
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 212701
Application*: WB, F, IC, MC
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Dog
Clone: CBYY-I0039
Application*: F, IP, MC
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-I0038
Application*: F, FN
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0017
Application*: F, IH, WB, E
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-1163
Application*: WB, P, C, IP
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-1162
Application*: F, FN, C, P, IP, WB
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 7H193
Application*: F
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: 6G2
Application*: F, IP
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6D254
Application*: F, IP, WB
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6A21
Application*: F, IH, IP, WB
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 68-5A5
Application*: IF/C, F
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 6.7
Application*: F
Target: ITGB2
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: 5K223
Application*: F, IH, IP, WB
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4K41
Application*: F, C, WB
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Rabbit
Clone: 3H1049
Application*: F, IH, IP
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: 3H1045
Application*: F, IP
Target: ITGB2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 3H1041
Application*: F, IH, IP
Target: ITGB2
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: 2E6
Application*: IP, C, F, I, B
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1B4/CD18
Application*: F
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: 13B115
Application*: E
Target: ITGB2
Host: Hamster
Antibody Isotype: IgG
Specificity: Hamster
Clone: 12G5/2E6
Application*: F, IP
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 118
Application*: F
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: 10E12
Application*: E, WB, P, IF/C, F
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4A118
Application*: IF/C, F
Target: ITGB2
Host: Rat
Antibody Isotype: IgG2b
Specificity: Human, Dog
Clone: 3H1058
Application*: F, IH, IP
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: 3H1055
Application*: F, IH, IP
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3EB
Application*: F
Target: ITGB2
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: M18/2
Application*: F, B, IF, IP, WB
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Dog, Pig
Clone: H52
Application*: F, B, IH, IP, WB
Target: ITGB2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EG1698
Application*: WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:40000
Target: ITGB2
Host: Rat
Antibody Isotype: IgG2b
Specificity: Dog, Guinea Pig
Clone: YFC118.3
Application*: C
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJC-3922
Application*: F
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle
Clone: IVA35
Application*: IP, F
Target: ITGB2
Host: Rat
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: CBWJC-3919
Application*: F, C
Target: ITGB2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBWJC-3918
Application*: WB, IP, P, F, IC
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-2250
Application*: E, F, IF
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Dog, Cattle, Cat, Horse, Human, Pig
Clone: CA1.4E9
Application*: C, IP, F, IF
Target: ITGB2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYC-2843
Application*: F
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: CBFYC-2842
Application*: E, IF
Target: ITGB2
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBFYC-2841
Application*: IP, IC, F, I, B
Target: ITGB2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYC-2840
Application*: F, IH
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYC-2839
Application*: F
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: CBFYC-2838
Application*: IF
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0193
Application*: F
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0318
Application*: WB, F, IH, IP, P, C, MC, FN
Target: ITGB2
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: P4H9
Application*: F, B, IH
More Infomation
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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