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Mouse Anti-ITGB2 Recombinant Antibody (3EB) (CBMAB-C1114-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
3EB
Antibody Isotype
IgG1
Application
FC

Basic Information

Immunogen
White blood cells
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
integrin subunit beta 2
Introduction
This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Entrez Gene ID
3689
UniProt ID
P05107
Alternative Names
LAD; CD18; MF17; MFI7; LCAMB; LFA-1; MAC-1
Function
Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (PubMed:29100055).
Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity (PubMed:15356110).
Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992, PubMed:28807980).
Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400).
Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).
In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407).
Biological Process
Aging Source: Ensembl
Amyloid-beta clearance Source: ARUK-UCL
Apoptotic process Source: UniProtKB
Cell adhesion Source: UniProtKB
Cell adhesion mediated by integrin Source: GO_Central
Cell-cell adhesion Source: BHF-UCL
Cell-cell adhesion via plasma-membrane adhesion molecules Source: ARUK-UCL
Cell-cell signaling Source: UniProtKB
Cell-matrix adhesion Source: UniProtKB
Cell migration Source: GO_Central
Cellular extravasation Source: Ensembl
Cellular response to low-density lipoprotein particle stimulus Source: UniProtKB
Cytokine-mediated signaling pathway Source: Reactome
Endodermal cell differentiation Source: UniProtKB
Endothelial cell migration Source: Ensembl
Extracellular matrix organization Source: Reactome
Heterotypic cell-cell adhesion Source: UniProtKB
Inflammatory response Source: UniProtKB
Integrin-mediated signaling pathway Source: UniProtKB
Leukocyte cell-cell adhesion Source: UniProtKB
Leukocyte migration Source: Reactome
Leukocyte migration involved in inflammatory response Source: Ensembl
Microglial cell activation Source: ARUK-UCL
Natural killer cell activation Source: Ensembl
Negative regulation of dopamine metabolic process Source: ARUK-UCL
Neutrophil chemotaxis Source: UniProtKB
Neutrophil degranulation Source: Reactome
Neutrophil migration Source: UniProtKB
Phagocytosis, engulfment Source: ARUK-UCL
Positive regulation of angiogenesis Source: Ensembl
Positive regulation of leukocyte adhesion to vascular endothelial cell Source: UniProtKB
Positive regulation of neuron death Source: ARUK-UCL
Positive regulation of neutrophil degranulation Source: UniProtKB
Positive regulation of NF-kappaB transcription factor activity Source: Ensembl
Positive regulation of nitric oxide biosynthetic process Source: Ensembl
Positive regulation of prostaglandin-E synthase activity Source: ARUK-UCL
Positive regulation of protein targeting to membrane Source: ARUK-UCL
Positive regulation of superoxide anion generation Source: UniProtKB
Receptor clustering Source: UniProtKB
Receptor internalization Source: UniProtKB
Receptor-mediated endocytosis Source: ARUK-UCL
Regulation of cell shape Source: UniProtKB
Regulation of immune response Source: Reactome
Regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
Toll-like receptor 4 signaling pathway Source: Reactome
Cellular Location
Cell membrane; Membrane raft
Involvement in disease
Leukocyte adhesion deficiency 1 (LAD1): LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions.
Topology
Extracellular: 23-700
Helical: 701-723
Cytoplasmic: 724-769
PTM
Both Ser-745 and Ser-756 become phosphorylated when T-cells are exposed to phorbol esters (PubMed:11700305). Phosphorylation on Thr-758 (but not on Ser-756) allows interaction with 14-3-3 proteins (PubMed:11700305, PubMed:16301335).
More Infomation

Liu, H., Wang, J., Luo, T., Zhen, Z., Liu, L., Zheng, Y., ... & Hu, X. (2023). Correlation between ITGB2 expression and clinical characterization of glioma and the prognostic significance of its methylation in low-grade glioma (LGG). Frontiers in endocrinology, 13, 1106120.

Xu, H., Zhang, A., Han, X., Li, Y., Zhang, Z., Song, L., ... & Lou, M. (2022). ITGB2 as a prognostic indicator and a predictive marker for immunotherapy in gliomas. Cancer Immunology, Immunotherapy, 1-16.

Zu, L., He, J., Zhou, N., Zeng, J., Zhu, Y., Tang, Q., ... & Xu, S. (2022). The profile and clinical significance of ITGB2 expression in non-Small-Cell lung cancer. Journal of Clinical Medicine, 11(21), 6421.

Sun, Z., Dang, Q., Liu, Z., Shao, B., Chen, C., Guo, Y., ... & Yuan, W. (2021). LINC01272/miR-876/ITGB2 axis facilitates the metastasis of colorectal cancer via epithelial-mesenchymal transition. Journal of Cancer, 12(13), 3909.

Wei, J., Huang, X. J., Huang, Y., Xiong, M. Y., Yao, X. Y., Huang, Z. N., ... & Cheng, P. (2021). Key immune-related gene ITGB2 as a prognostic signature for acute myeloid leukemia. Annals of Translational Medicine, 9(17).

George, L., Menden, H., Xia, S., Yu, W., Holmes, A., Johnston, J., ... & Sampath, V. (2021). ITGB2 (Integrin β2) immunomodulatory gene variants in premature infants with necrotizing enterocolitis. Journal of pediatric gastroenterology and nutrition, 72(2), e37-e41.

Li, J., Zhang, Z., Feng, X., Shen, Z., Sun, J., Zhang, X., ... & Wang, Z. (2021). Stanniocalcin-2 promotes cell EMT and glycolysis via activating ITGB2/FAK/SOX6 signaling pathway in nasopharyngeal carcinoma. Cell Biology and Toxicology, 1-14.

Yang, M., Qin, Q., Zhu, J., Guo, Y., Yin, T., Wu, H., & Wang, C. (2020). Long noncoding RNA ITGB2‐AS1 promotes growth and metastasis through miR‐4319/RAF1 axis in pancreatic ductal adenocarcinoma. Journal of Cellular Physiology.

Dai, J., Xu, L. J., Han, G. D., Jiang, H. T., Sun, H. L., Zhu, G. T., & Tang, X. M. (2018). Down-regulation of long non-coding RNA ITGB2-AS1 inhibits osteosarcoma proliferation and metastasis by repressing Wnt/β-catenin signalling and predicts favourable prognosis. Artificial cells, nanomedicine, and biotechnology, 46(sup3), 783-790.

Liu, M., Gou, L., Xia, J., Wan, Q., Jiang, Y., Sun, S., ... & Zhang, Y. (2018). LncRNA ITGB2-AS1 could promote the migration and invasion of breast cancer cells through up-regulating ITGB2. International journal of molecular sciences, 19(7), 1866.

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For research use only. Not intended for any clinical use.

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