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Mouse Anti-ITGB2 Recombinant Antibody (CA1.4E9) (CBMAB-C3085WJ)


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Summary

Host Animal
Mouse
Specificity
Dog, Cattle, Cat, Horse, Human, Pig
Clone
CA1.4E9
Antibody Isotype
IgG1
Application
IHC-Fr, IP, FC, IF

Basic Information

Specificity
Dog, Cattle, Cat, Horse, Human, Pig
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1.0 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
integrin subunit beta 2
Introduction
This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Entrez Gene ID
Human3689
Dog403770
Pig396943
Cattle281877
Cat101087258
Horse100056128
UniProt ID
HumanP05107
DogF1Q1H6
PigP53714
CattleP32592
CatA0A5K1TUQ9
HorseA0A5F5PG05
Alternative Names
LAD; CD18; MF17; MFI7; LCAMB; LFA-1; MAC-1
Function
Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (PubMed:29100055).
Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity (PubMed:15356110).
Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992, PubMed:28807980).
Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400).
Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).
In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407).
Biological Process
Aging Source: Ensembl
Amyloid-beta clearance Source: ARUK-UCL
Apoptotic process Source: UniProtKB
Cell adhesion Source: UniProtKB
Cell adhesion mediated by integrin Source: GO_Central
Cell-cell adhesion Source: BHF-UCL
Cell-cell adhesion via plasma-membrane adhesion molecules Source: ARUK-UCL
Cell-cell signaling Source: UniProtKB
Cell-matrix adhesion Source: UniProtKB
Cell migration Source: GO_Central
Cellular extravasation Source: Ensembl
Cellular response to low-density lipoprotein particle stimulus Source: UniProtKB
Cytokine-mediated signaling pathway Source: Reactome
Endodermal cell differentiation Source: UniProtKB
Endothelial cell migration Source: Ensembl
Extracellular matrix organization Source: Reactome
Heterotypic cell-cell adhesion Source: UniProtKB
Inflammatory response Source: UniProtKB
Integrin-mediated signaling pathway Source: UniProtKB
Leukocyte cell-cell adhesion Source: UniProtKB
Leukocyte migration Source: Reactome
Leukocyte migration involved in inflammatory response Source: Ensembl
Microglial cell activation Source: ARUK-UCL
Natural killer cell activation Source: Ensembl
Negative regulation of dopamine metabolic process Source: ARUK-UCL
Neutrophil chemotaxis Source: UniProtKB
Neutrophil degranulation Source: Reactome
Neutrophil migration Source: UniProtKB
Phagocytosis, engulfment Source: ARUK-UCL
Positive regulation of angiogenesis Source: Ensembl
Positive regulation of leukocyte adhesion to vascular endothelial cell Source: UniProtKB
Positive regulation of neuron death Source: ARUK-UCL
Positive regulation of neutrophil degranulation Source: UniProtKB
Positive regulation of NF-kappaB transcription factor activity Source: Ensembl
Positive regulation of nitric oxide biosynthetic process Source: Ensembl
Positive regulation of prostaglandin-E synthase activity Source: ARUK-UCL
Positive regulation of protein targeting to membrane Source: ARUK-UCL
Positive regulation of superoxide anion generation Source: UniProtKB
Receptor clustering Source: UniProtKB
Receptor internalization Source: UniProtKB
Receptor-mediated endocytosis Source: ARUK-UCL
Regulation of cell shape Source: UniProtKB
Regulation of immune response Source: Reactome
Regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
Toll-like receptor 4 signaling pathway Source: Reactome
Cellular Location
Cell membrane; Membrane raft
Involvement in disease
Leukocyte adhesion deficiency 1 (LAD1): LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions.
Topology
Extracellular: 23-700
Helical: 701-723
Cytoplasmic: 724-769
PTM
Both Ser-745 and Ser-756 become phosphorylated when T-cells are exposed to phorbol esters (PubMed:11700305). Phosphorylation on Thr-758 (but not on Ser-756) allows interaction with 14-3-3 proteins (PubMed:11700305, PubMed:16301335).
More Infomation

Liu, H., Wang, J., Luo, T., Zhen, Z., Liu, L., Zheng, Y., ... & Hu, X. (2023). Correlation between ITGB2 expression and clinical characterization of glioma and the prognostic significance of its methylation in low-grade glioma (LGG). Frontiers in endocrinology, 13, 1106120.

Xu, H., Zhang, A., Han, X., Li, Y., Zhang, Z., Song, L., ... & Lou, M. (2022). ITGB2 as a prognostic indicator and a predictive marker for immunotherapy in gliomas. Cancer Immunology, Immunotherapy, 1-16.

Zu, L., He, J., Zhou, N., Zeng, J., Zhu, Y., Tang, Q., ... & Xu, S. (2022). The profile and clinical significance of ITGB2 expression in non-Small-Cell lung cancer. Journal of Clinical Medicine, 11(21), 6421.

Sun, Z., Dang, Q., Liu, Z., Shao, B., Chen, C., Guo, Y., ... & Yuan, W. (2021). LINC01272/miR-876/ITGB2 axis facilitates the metastasis of colorectal cancer via epithelial-mesenchymal transition. Journal of Cancer, 12(13), 3909.

Wei, J., Huang, X. J., Huang, Y., Xiong, M. Y., Yao, X. Y., Huang, Z. N., ... & Cheng, P. (2021). Key immune-related gene ITGB2 as a prognostic signature for acute myeloid leukemia. Annals of Translational Medicine, 9(17).

George, L., Menden, H., Xia, S., Yu, W., Holmes, A., Johnston, J., ... & Sampath, V. (2021). ITGB2 (Integrin β2) immunomodulatory gene variants in premature infants with necrotizing enterocolitis. Journal of pediatric gastroenterology and nutrition, 72(2), e37-e41.

Li, J., Zhang, Z., Feng, X., Shen, Z., Sun, J., Zhang, X., ... & Wang, Z. (2021). Stanniocalcin-2 promotes cell EMT and glycolysis via activating ITGB2/FAK/SOX6 signaling pathway in nasopharyngeal carcinoma. Cell Biology and Toxicology, 1-14.

Yang, M., Qin, Q., Zhu, J., Guo, Y., Yin, T., Wu, H., & Wang, C. (2020). Long noncoding RNA ITGB2‐AS1 promotes growth and metastasis through miR‐4319/RAF1 axis in pancreatic ductal adenocarcinoma. Journal of Cellular Physiology.

Dai, J., Xu, L. J., Han, G. D., Jiang, H. T., Sun, H. L., Zhu, G. T., & Tang, X. M. (2018). Down-regulation of long non-coding RNA ITGB2-AS1 inhibits osteosarcoma proliferation and metastasis by repressing Wnt/β-catenin signalling and predicts favourable prognosis. Artificial cells, nanomedicine, and biotechnology, 46(sup3), 783-790.

Liu, M., Gou, L., Xia, J., Wan, Q., Jiang, Y., Sun, S., ... & Zhang, Y. (2018). LncRNA ITGB2-AS1 could promote the migration and invasion of breast cancer cells through up-regulating ITGB2. International journal of molecular sciences, 19(7), 1866.

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For research use only. Not intended for any clinical use.

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