ITGA5

The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit. This subunit associates with the beta 1 subunit to form a fibronectin receptor. This integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung cancer patients. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015]

Full Name

Integrin Subunit Alpha 5

Function

Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877).
ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881).
ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430).
ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (PubMed:31331973).
(Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human metapneumovirus.
(Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human parvovirus B19.
(Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

Biological Process

AngiogenesisManual Assertion Based On ExperimentTAS:BHF-UCL
CD40 signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Cell adhesionManual Assertion Based On ExperimentIDA:UniProtKB
Cell adhesion mediated by integrinManual Assertion Based On ExperimentIDA:UniProtKB
Cell-cell adhesion mediated by integrinIEA:Ensembl
Cell-substrate adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Cell-substrate junction assemblyIEA:Ensembl
Endodermal cell differentiationManual Assertion Based On ExperimentIMP:UniProtKB
Female pregnancyIEA:Ensembl
Heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesIEA:Ensembl
Heterotypic cell-cell adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Integrin-mediated signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Leukocyte cell-cell adhesionIEA:Ensembl
MemoryIEA:Ensembl
Negative regulation of anoikisManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of cell migrationIEA:Ensembl
Positive regulation of cell-substrate adhesionIEA:Ensembl
Positive regulation of peptidyl-tyrosine phosphorylationManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of sprouting angiogenesisManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of vascular endothelial growth factor receptor signaling pathwayManual Assertion Based On ExperimentTAS:BHF-UCL
Wound healing, spreading of epidermal cellsManual Assertion Based On ExperimentIEP:BHF-UCL

Cellular Location

Membrane; Cell junction, focal adhesion; Cell surface

Topology

Extracellular: 42-995
Helical: 996-1021
Cytoplasmic: 1022-1049

PTM

Proteolytic cleavage by PCSK5 mediates activation of the precursor.

Anti-ITGA5 antibodies

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)