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Human Anti-ITGA5 Recombinant Antibody (M200) (CBMAB-AP2759LY)


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Summary

Host Animal
Human
Specificity
Human
Clone
M200
Antibody Isotype
IgG4
Application
Block, ELISA, FC, IF, IHC

Basic Information

Specificity
Human
Antibody Isotype
IgG4
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Integrin Subunit Alpha 5
Introduction
The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit. This subunit associates with the beta 1 subunit to form a fibronectin receptor. This integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung cancer patients. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015]
Entrez Gene ID
3678
UniProt ID
P08648
Alternative Names
Integrin Subunit Alpha 5
Function
Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877).
ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881).
ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430).
ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (PubMed:31331973).
(Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human metapneumovirus.
(Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human parvovirus B19.
(Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
Biological Process
AngiogenesisManual Assertion Based On ExperimentTAS:BHF-UCL
CD40 signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Cell adhesionManual Assertion Based On ExperimentIDA:UniProtKB
Cell adhesion mediated by integrinManual Assertion Based On ExperimentIDA:UniProtKB
Cell-cell adhesion mediated by integrinIEA:Ensembl
Cell-substrate adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Cell-substrate junction assemblyIEA:Ensembl
Endodermal cell differentiationManual Assertion Based On ExperimentIMP:UniProtKB
Female pregnancyIEA:Ensembl
Heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesIEA:Ensembl
Heterotypic cell-cell adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Integrin-mediated signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Leukocyte cell-cell adhesionIEA:Ensembl
MemoryIEA:Ensembl
Negative regulation of anoikisManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of cell migrationIEA:Ensembl
Positive regulation of cell-substrate adhesionIEA:Ensembl
Positive regulation of peptidyl-tyrosine phosphorylationManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of sprouting angiogenesisManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of vascular endothelial growth factor receptor signaling pathwayManual Assertion Based On ExperimentTAS:BHF-UCL
Wound healing, spreading of epidermal cellsManual Assertion Based On ExperimentIEP:BHF-UCL
Cellular Location
Membrane; Cell junction, focal adhesion; Cell surface
Topology
Extracellular: 42-995
Helical: 996-1021
Cytoplasmic: 1022-1049
PTM
Proteolytic cleavage by PCSK5 mediates activation of the precursor.
More Infomation

Wang, J. F., Chen, Y. Y., Zhang, S. W., Zhao, K., Qiu, Y., Wang, Y., ... & Chen, J. Q. (2022). ITGA5 promotes tumor progression through the activation of the FAK/AKT signaling pathway in human gastric cancer. Oxidative Medicine and Cellular Longevity, 2022.

Zhou, C., Shen, Y., Wei, Z., Shen, Z., Tang, M., Shen, Y., & Deng, H. (2022). ITGA5 is an independent prognostic biomarker and potential therapeutic target for laryngeal squamous cell carcinoma. Journal of Clinical Laboratory Analysis, 36(2), e24228.

Assidicky, R., Tokat, U. M., Tarman, I. O., Saatci, O., Ersan, P. G., Raza, U., ... & Sahin, O. (2022). Targeting HIF1-alpha/miR-326/ITGA5 axis potentiates chemotherapy response in triple-negative breast cancer. Breast cancer research and treatment, 193(2), 331-348.

Zhu, H., Wang, G., Zhu, H., & Xu, A. (2021). ITGA5 is a prognostic biomarker and correlated with immune infiltration in gastrointestinal tumors. BMC cancer, 21, 1-14.

Jiang, Z., Wei, J., Yang, W., Li, W., Liu, F., Yan, X., ... & Li, J. (2020). MicroRNA-26a inhibits wound healing through decreased keratinocytes migration by regulating ITGA5 through PI3K/AKT signaling pathway. Bioscience Reports, 40(9), BSR20201361.

Feng, C., Jin, X., Han, Y., Guo, R., Zou, J., Li, Y., & Wang, Y. (2020). Expression and prognostic analyses of ITGA3, ITGA5, and ITGA6 in head and neck squamous cell carcinoma. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 26, e926800-1.

Yan, T., & Ye, X. X. (2019). MicroRNA-328-3p inhibits the tumorigenesis of bladder cancer through targeting ITGA5 and inactivating PI3K/AKT pathway. European Review for Medical & Pharmacological Sciences, 23(12).

Deng, Y., Wan, Q., & Yan, W. (2019). Integrin α5/ITGA5 promotes the proliferation, migration, invasion and progression of oral squamous carcinoma by epithelial–mesenchymal transition. Cancer management and research, 9609-9620.

Yu, M., Chu, S., Fei, B., Fang, X., & Liu, Z. (2019). O-GlcNAcylation of ITGA5 facilitates the occurrence and development of colorectal cancer. Experimental Cell Research, 382(2), 111464.

Kuninty, P. R., Bansal, R., De Geus, S. W., Mardhian, D. F., Schnittert, J., van Baarlen, J., ... & Prakash, J. (2019). ITGA5 inhibition in pancreatic stellate cells attenuates desmoplasia and potentiates efficacy of chemotherapy in pancreatic cancer. Science advances, 5(9), eaax2770.

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For research use only. Not intended for any clinical use.

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