ITGA3

The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 3 subunit. This subunit joins with a beta 1 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. Expression of this gene may be correlated with breast cancer metastasis. [provided by RefSeq, Oct 2015]

Integrin Subunit Alpha 3

Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration.
(Microbial infection) Integrin ITGA3:ITGB1 may act as a receptor for R.delemar CotH7 in alveolar epithelial cells, which may be an early step in pulmonary mucormycosis disease progression.

Cell-matrix adhesionManual Assertion Based On ExperimentTAS:ProtInc
Dendritic spine maintenanceISS:ARUK-UCL
Exploration behaviorISS:ARUK-UCL
Heart developmentIEA:Ensembl
Integrin-mediated signaling pathwayIEA:UniProtKB-KW
Lung developmentManual Assertion Based On ExperimentIMP:UniProtKB
Maternal process involved in female pregnancyIEA:Ensembl
MemoryIEA:Ensembl
Mesodermal cell differentiationManual Assertion Based On ExperimentIEP:UniProtKB
Negative regulation of cell projection organizationIEA:Ensembl
Negative regulation of Rho protein signal transductionISS:ARUK-UCL
Nephron developmentManual Assertion Based On ExperimentIMP:UniProtKB
Neuron migrationIEA:Ensembl
Positive regulation of cell-substrate adhesionIEA:Ensembl
Positive regulation of epithelial cell migrationIEA:Ensembl
Positive regulation of gene expressionIEA:Ensembl
Positive regulation of neuron projection developmentIEA:Ensembl
Positive regulation of protein localization to plasma membraneManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of BMP signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of transforming growth factor beta receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of Wnt signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Renal filtrationManual Assertion Based On ExperimentIMP:UniProtKB
Response to gonadotropinIEA:Ensembl
Response to xenobiotic stimulusIEA:Ensembl
Skin developmentManual Assertion Based On ExperimentIMP:UniProtKB

Cell membrane; Cell membrane; Cell projection, invadopodium membrane; Cell projection, filopodium membrane. Enriched preferentially at invadopodia, cell membrane protrusions that correspond to sites of cell invasion, in a collagen-dependent manner.

Interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa, congenital (ILNEB):
A multiorgan disorder characterized by congenital nephrotic syndrome, interstitial lung disease, and epidermolysis bullosa. The respiratory and renal features predominate, and lung involvement accounts for the lethal course of the disease.

Extracellular: 33-991
Helical: 992-1014
Cytoplasmic: 1015-1051

Isoform 1, but not isoform 2, is phosphorylated on serine residues. Phosphorylation increases after phorbol 12-myristate 13-acetate stimulation.