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Mouse Anti-ITGA3 Antibody (P1B5) (CBMAB-0089-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
P1B5
Antibody Isotype
IgG1
Application
FC, Blocking, IF, IHC, IP

Basic Information

Immunogen
HT1080 human fibrosarcoma cell line
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
Binding to NITVKN (aa 75-80)

Target

Full Name
Integrin Subunit Alpha 3
Introduction
The gene encodes a member of the integrin alpha chain family of proteins. ITGA3 is an integrin alpha subunit. Together with beta-1 subunit, it makes up half of the α3β1 integrin duplex that plays a role in neural migration and corticogenesis, acted upon by such factors as netrin-1 and reelin. Expression of this gene may be correlated with breast cancer metastasis.
Entrez Gene ID
3675
UniProt ID
P26006
Alternative Names
CD49c; GAP-B3; MSK18; VCA-2; VLA3a
Function
Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration.
(Microbial infection) Integrin ITGA3:ITGB1 may act as a receptor for R.delemar CotH7 in alveolar epithelial cells, which may be an early step in pulmonary mucormycosis disease progression.
Biological Process
Cell-matrix adhesionManual Assertion Based On ExperimentTAS:ProtInc
Dendritic spine maintenanceISS:ARUK-UCL
Exploration behaviorISS:ARUK-UCL
Heart developmentIEA:Ensembl
Integrin-mediated signaling pathwayIEA:UniProtKB-KW
Lung developmentManual Assertion Based On ExperimentIMP:UniProtKB
Maternal process involved in female pregnancyIEA:Ensembl
MemoryIEA:Ensembl
Mesodermal cell differentiationManual Assertion Based On ExperimentIEP:UniProtKB
Negative regulation of cell projection organizationIEA:Ensembl
Negative regulation of Rho protein signal transductionISS:ARUK-UCL
Nephron developmentManual Assertion Based On ExperimentIMP:UniProtKB
Neuron migrationIEA:Ensembl
Positive regulation of cell-substrate adhesionIEA:Ensembl
Positive regulation of epithelial cell migrationIEA:Ensembl
Positive regulation of gene expressionIEA:Ensembl
Positive regulation of neuron projection developmentIEA:Ensembl
Positive regulation of protein localization to plasma membraneManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of BMP signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of transforming growth factor beta receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of Wnt signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Renal filtrationManual Assertion Based On ExperimentIMP:UniProtKB
Response to gonadotropinIEA:Ensembl
Response to xenobiotic stimulusIEA:Ensembl
Skin developmentManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cell membrane; Cell membrane; Cell projection, invadopodium membrane; Cell projection, filopodium membrane. Enriched preferentially at invadopodia, cell membrane protrusions that correspond to sites of cell invasion, in a collagen-dependent manner.
Involvement in disease
Interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa, congenital (ILNEB):
A multiorgan disorder characterized by congenital nephrotic syndrome, interstitial lung disease, and epidermolysis bullosa. The respiratory and renal features predominate, and lung involvement accounts for the lethal course of the disease.
Topology
Extracellular: 33-991
Helical: 992-1014
Cytoplasmic: 1015-1051
PTM
Isoform 1, but not isoform 2, is phosphorylated on serine residues. Phosphorylation increases after phorbol 12-myristate 13-acetate stimulation.
More Infomation

Islam, M. K., Syed, P., Dhondt, B., Gidwani, K., Pettersson, K., Lamminmäki, U., & Leivo, J. (2021). Detection of bladder cancer with aberrantly fucosylated ITGA3. Analytical biochemistry, 628, 114283.

Li, Y., Li, F., Bai, X., Li, Y., Ni, C., Zhao, X., & Zhang, D. (2021). ITGA3 is associated with immune cell infiltration and serves as a favorable prognostic biomarker for breast cancer. Frontiers in oncology, 11, 658547.

Zhang, H., Cui, X., Li, X., & Li, L. (2020). ITGA3 interacts with VASP to regulate stemness and epithelial-mesenchymal transition of breast cancer cells. Gene, 734, 144396.

Tian, L., Chen, M., He, Q., Yan, Q., & Zhai, C. (2020). MicroRNA‑199a‑5p suppresses cell proliferation, migration and invasion by targeting ITGA3 in colorectal cancer. Molecular medicine reports, 22(3), 2307-2317.

Wang, J. R., Liu, B., Zhou, L., & Huang, Y. X. (2019). MicroRNA-124-3p suppresses cell migration and invasion by targeting ITGA3 signaling in bladder cancer. Cancer Biomarkers, 24(2), 159-172.

Jiao, Y., Li, Y., Liu, S., Chen, Q., & Liu, Y. (2019). ITGA3 serves as a diagnostic and prognostic biomarker for pancreatic cancer. OncoTargets and therapy, 12, 4141.

Huang, Y., Kong, Y., Zhang, L., He, T., Zhou, X., Yan, Y., ... & Wang, W. (2018). High expression of ITGA3 promotes proliferation and cell cycle progression and indicates poor prognosis in intrahepatic cholangiocarcinoma. BioMed Research International, 2018.

Idichi, T., Seki, N., Kurahara, H., Fukuhisa, H., Toda, H., Shimonosono, M., ... & Natsugoe, S. (2018). Involvement of anti-tumor miR-124-3p and its targets in the pathogenesis of pancreatic ductal adenocarcinoma: Direct regulation of ITGA3 and ITGB1 by miR-124-3p. Oncotarget, 9(48), 28849.

Zhang, X., Li, X. F., Gu, Z. P., Yang, A. G., Zhang, R., Li, J. P., & Sun, J. Y. (2018). A miR-124/ITGA3 axis contributes to colorectal cancer metastasis by regulating anoikis susceptibility. Biochemical and Biophysical Research Communications, 501(3), 758-764.

Tang, X. R., Wen, X., He, Q. M., Li, Y. Q., Ren, X. Y., Yang, X. J., ... & Liu, N. (2018). MicroRNA-101 inhibits invasion and angiogenesis through targeting ITGA3 and its systemic delivery inhibits lung metastasis in nasopharyngeal carcinoma. Cell Death & Disease, 8(1), e2566-e2566.

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For research use only. Not intended for any clinical use.

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