ISL1

This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young. [provided by RefSeq, Jul 2008]

ISL LIM Homeobox 1

DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina. Involved in the specification of motor neurons in cooperation with LHX3 and LDB1. Binds to insulin gene enhancer sequences. Essential for heart development. Marker of one progenitor cell population that give rise to the outflow tract, right ventricle, a subset of left ventricular cells, and a large number of atrial cells as well, its function is required for these progenitors to contribute to the heart. Controls the expression of FGF and BMP growth factors in this cell population and is required for proliferation and survival of cells within pharyngeal foregut endoderm and adjacent splanchnic mesoderm as well as for migration of cardiac progenitors into the heart (By similarity).

Atrial septum morphogenesisISS:BHF-UCL
Axon regenerationIEA:Ensembl
AxonogenesisManual Assertion Based On ExperimentIBA:GO_Central
Cardiac cell fate determinationManual Assertion Based On ExperimentIDA:BHF-UCL
Cardiac muscle cell myoblast differentiationIEA:Ensembl
Cardiac right ventricle morphogenesisISS:BHF-UCL
Cellular response to glucocorticoid stimulusISS:BHF-UCL
Endocardial cushion morphogenesisISS:BHF-UCL
Heart developmentISS:UniProtKB
InnervationISS:BHF-UCL
Mesenchymal cell differentiationISS:BHF-UCL
Negative regulation of canonical Wnt signaling pathwayIEA:Ensembl
Negative regulation of epithelial cell proliferationIEA:Ensembl
Negative regulation of inflammatory responseISS:BHF-UCL
Negative regulation of intracellular estrogen receptor signaling pathwayISS:BHF-UCL
Negative regulation of neuron apoptotic processISS:BHF-UCL
Negative regulation of neuron differentiationIEA:Ensembl
Negative regulation of protein-containing complex assemblyISS:BHF-UCL
Negative regulation of transcription by RNA polymerase IIISS:BHF-UCL
Neural crest cell migrationIEA:Ensembl
Neuron fate specificationISS:BHF-UCL
Outflow tract morphogenesisISS:BHF-UCL
Outflow tract septum morphogenesisISS:BHF-UCL
Pancreas developmentISS:BHF-UCL
Peripheral nervous system neuron axonogenesisISS:BHF-UCL
Pharyngeal system developmentISS:BHF-UCL
Pituitary gland developmentIEA:Ensembl
Positive regulation of angiogenesisISS:BHF-UCL
Positive regulation of cell differentiationISS:UniProtKB
Positive regulation of cell population proliferationIEA:Ensembl
Positive regulation of DNA bindingIEA:Ensembl
Positive regulation of epithelial to mesenchymal transitionIEA:Ensembl
Positive regulation of granulocyte colony-stimulating factor productionISS:BHF-UCL
Positive regulation of granulocyte macrophage colony-stimulating factor productionISS:BHF-UCL
Positive regulation of histone acetylationIEA:Ensembl
Positive regulation of insulin secretion1 PublicationIC:BHF-UCL
Positive regulation of interferon-gamma productionISS:BHF-UCL
Positive regulation of interleukin-1 alpha productionISS:BHF-UCL
Positive regulation of interleukin-1 beta productionISS:BHF-UCL
Positive regulation of interleukin-12 productionISS:BHF-UCL
Positive regulation of interleukin-6 productionISS:BHF-UCL
Positive regulation of macrophage colony-stimulating factor productionISS:BHF-UCL
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIGI:ParkinsonsUK-UCL
Positive regulation of tumor necrosis factor productionISS:BHF-UCL
Positive regulation of tyrosine phosphorylation of STAT proteinIEA:Ensembl
Positive regulation of vascular endothelial growth factor productionISS:BHF-UCL
Regulation of heart rate by cardiac conductionISS:BHF-UCL
Regulation of secondary heart field cardioblast proliferationIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Retinal ganglion cell axon guidanceIEA:Ensembl
Secondary heart field specificationManual Assertion Based On ExperimentIMP:BHF-UCL
Sensory system developmentISS:BHF-UCL
Sinoatrial node cell developmentISS:BHF-UCL
Spinal cord motor neuron cell fate specificationIEA:Ensembl
Spinal cord motor neuron differentiationISS:BHF-UCL
Trigeminal nerve developmentISS:BHF-UCL
Ventricular cardiac muscle tissue morphogenesisISS:BHF-UCL
Visceral motor neuron differentiationIEA:Ensembl

Nucleus

Phosphorylated.