IQGAP1

This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines.

IQ motif containing GTPase activating protein 1

Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth (PubMed:15695813).
May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed:20883816).

Cell migrationManual Assertion Based On ExperimentIMP:ARUK-UCL
Cellular response to calcium ionManual Assertion Based On ExperimentIDA:BHF-UCL
Cellular response to epidermal growth factor stimulusManual Assertion Based On ExperimentIMP:BHF-UCL
Cellular response to platelet-derived growth factor stimulusIEA:Ensembl
Epidermal growth factor receptor signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Fibroblast growth factor receptor signaling pathwayIEA:Ensembl
Fibroblast migrationIEA:Ensembl
Glomerular visceral epithelial cell developmentISS:UniProtKB
Negative regulation of dephosphorylationIEA:Ensembl
Neuron projection extensionManual Assertion Based On ExperimentIMP:UniProtKB
Platelet-derived growth factor receptor signaling pathwayIEA:Ensembl
Positive regulation of MAPK cascadeManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of protein kinase activityManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of actin cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cytokine productionIEA:Ensembl
Regulation of GTPase activityIEA:InterPro
Regulation of mitotic cell cycleManual Assertion Based On ExperimentIMP:UniProtKB
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cell membrane; Nucleus; Cytoplasm. Subcellular distribution is regulated by the cell cycle, nuclear levels increase at G1/S phase (PubMed:20883816).

Phosphorylation of Ser-1443 by PKC/PRKCE prevents interaction between C1 and C2, allowing binding of nucleotide-free CDC42. Ser-1443 phosphorylation enhances the ability to promote neurite outgrowth.