ING1

This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Full Name

Inhibitor Of Growth Family Member 1

Function

Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.

Biological Process

Cell cycleIEA:UniProtKB-KW
Negative regulation of cell growth1 PublicationNAS:UniProtKB
Negative regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIBA:GO_Central
Protein import into nucleusIEA:Ensembl
Regulation of cell deathIEA:Ensembl
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus

Involvement in disease

Squamous cell carcinoma of the head and neck (HNSCC):
A non-melanoma skin cancer affecting the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes.

Anti-ING1 antibodies

Recombinant Mouse Anti-ING1 Recombinant Antibody (Cab 1) (CBMAB-XB0616-YC)

Datasheet

SDS

Target: ING1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse

Clone: Cab 1

Application*: E, IF, WB

Recombinant Mouse Anti-ING1 Recombinant Antibody (Cabs 2-9) (CBMAB-XB0617-YC)

Datasheet

SDS

Target: ING1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: Cabs 2-9

Application*: E, IF, WB

Mouse Anti-ING1 Recombinant Antibody (2E1) (CBMAB-A4472-LY)

Datasheet

SDS

Target: ING1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2E1

Application*: WB, E

Mouse Anti-ING1 Antibody (1C2) (CBMAB-0530-YC)

Datasheet

SDS

Target: ING1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1C2

Application*: WB, M

Mouse Anti-ING1 Recombinant Antibody (1C9) (CBMAB-I0644-YY)

Datasheet

SDS

Target: ING1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1C9

Application*: E, WB

Mouse Anti-ING1 Recombinant Antibody (CBYY-I0246) (CBMAB-I0645-YY)

Datasheet

SDS

Target: ING1

Host: Mouse

Antibody Isotype: IgM, κ

Specificity: Human

Clone: CBYY-I0246

Application*: E, WB

Mouse Anti-ING1 Recombinant Antibody (CBYY-I0631) (CBMAB-I1405-YY)

Datasheet

SDS

Target: ING1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: CBYY-I0631

Application*: WB

Mouse Anti-ING1 Recombinant Antibody (CBYY-I0632) (CBMAB-I1406-YY)

Datasheet

SDS

Target: ING1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-I0632

Application*: IH

Mouse Anti-ING1 Recombinant Antibody (CBYY-I1053) (CBMAB-I2221-YY)

Datasheet

SDS

Target: ING1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYY-I1053

Application*: E, WB

Rabbit Anti-ING1 Recombinant Antibody (CBYY-I1663) (CBMAB-I2833-YY)

Datasheet

SDS

Target: ING1

Host: Rabbit

Specificity: Human, Mouse, Rat, Monkey

Clone: CBYY-I1663

Application*: WB, IP

ING1 Matched Antibody Pair (641) (APMAB-641LY)

Datasheet

SDS

Target: ING1

Specificity: Human

ING1 Matched Antibody Pair (642) (APMAB-642LY)

Datasheet

SDS

Target: ING1

Specificity: Human

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)