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IL7R

The protein encoded by this gene is a receptor for interleukin 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukins 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in V(D)J recombination during lymphocyte development. Defects in this gene may be associated with severe combined immunodeficiency (SCID). Alternatively spliced transcript variants have been found.
Full Name
Interleukin 7 Receptor
Alternative Names
Interleukin 7 Receptor
Function
Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
Biological Process
B cell proliferationIEA:Ensembl
Cell morphogenesisIEA:Ensembl
Cell surface receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Defense response to Gram-positive bacteriumIEA:Ensembl
Homeostasis of number of cellsIEA:Ensembl
Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Lymph node developmentIEA:Ensembl
Negative regulation of T cell apoptotic processIEA:Ensembl
Negative regulation of T cell mediated cytotoxicityIEA:Ensembl
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of gene expressionIEA:Ensembl
Positive regulation of receptor signaling pathway via STATManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of T cell differentiation in thymusIEA:Ensembl
Regulation of cell sizeIEA:Ensembl
Regulation of DNA recombinationManual Assertion Based On ExperimentTAS:ProtInc
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
T cell differentiationIEA:Ensembl
Cellular Location
Isoform 1&3: Cell membrane
Isoform 4: Secreted
Involvement in disease
Severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+) SCID):
A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.
Multiple sclerosis 3 (MS3):
A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheath, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease.
Topology
Extracellular: 21-239
Helical: 240-264
Cytoplasmic: 265-459
PTM
N-glycosylated IL-7Ralpha binds IL7 300-fold more tightly than the unglycosylated form.

Anti-IL7R antibodies

+ Filters
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Target: IL7R
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: AG115
Application*: B, MC, F, IF, C, IP, WB
Target: IL7R
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 40131
Application*: C, WB
Target: IL7R
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C1161
Application*: F, WB
Target: IL7R
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: SB/14
Application*: F
Target: IL7R
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: RDR5
Application*: F
Target: IL7R
Host: Rat
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: SB/199
Application*: F
Target: IL7R
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: A019D5
Application*: FC
Target: IL7R
Host: Rat
Antibody Isotype: IgG2a, λ
Specificity: Mouse
Clone: CBWJC-3843
Application*: F
Target: IL7R
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYY-I0238
Application*: E, F
Target: IL7R
Host: Mouse
Antibody Isotype: IgG2b, λ
Specificity: Human
Clone: CBYY-I0239
Application*: WB, F, IH, P, MC
Target: IL7R
Host: Rat
Antibody Isotype: IgG, κ
Specificity: Mouse
Clone: CBYY-I0726
Application*: WB
Target: IL7R
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: 73N8F2
Application*: P, WB
Target: IL7R
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-I0840
Application*: F
Target: IL7R
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1048
Application*: E
Target: IL7R
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYY-I1195
Application*: WB
Target: IL7R
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBYY-I1418
Application*: E
Target: IL7R
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBYY-I1432
Application*: E, WB
Target: IL7R
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYY-I1512
Application*: F, MC
Target: IL7R
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBFYC-2780
Application*: F
Target: IL7R
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: MB15-18C9
Application*: F
Target: IL7R
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0897
Application*: F
Target: IL7R
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: A7R34
Application*: F, FN, C, IP, N
Target: IL7R
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Monkey
Clone: CBWJC-2204
Application*: F, C
Target: IL7R
Host: Rat
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: CBWJC-2205
Application*: F
Target: IL7R
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJC-2206
Application*: F
Target: IL7R
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0341
Application*: WB, F, MC
Target: IL7R
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: A595
Application*: FC, IF, IHC, IP, WB
Target: IL7R
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 14L151
Application*: F
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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