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Human Anti-IL7R Recombinant Antibody (CBXC-0897) (CBMAB-C2012-CQ)


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Summary

Host Animal
Human
Specificity
Human
Clone
CBXC-0897
Antibody Isotype
IgG1
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Buffer containing stabilizer
Preservative
0.05% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Interleukin 7 Receptor
Introduction
The protein encoded by this gene is a receptor for interleukin 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukins 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in V(D)J recombination during lymphocyte development. Defects in this gene may be associated with severe combined immunodeficiency (SCID). Alternatively spliced transcript variants have been found.
Entrez Gene ID
3575
UniProt ID
P16871
Alternative Names
Interleukin 7 Receptor
Function
Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
Biological Process
B cell proliferationIEA:Ensembl
Cell morphogenesisIEA:Ensembl
Cell surface receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Defense response to Gram-positive bacteriumIEA:Ensembl
Homeostasis of number of cellsIEA:Ensembl
Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Lymph node developmentIEA:Ensembl
Negative regulation of T cell apoptotic processIEA:Ensembl
Negative regulation of T cell mediated cytotoxicityIEA:Ensembl
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of gene expressionIEA:Ensembl
Positive regulation of receptor signaling pathway via STATManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of T cell differentiation in thymusIEA:Ensembl
Regulation of cell sizeIEA:Ensembl
Regulation of DNA recombinationManual Assertion Based On ExperimentTAS:ProtInc
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
T cell differentiationIEA:Ensembl
Cellular Location
Isoform 1&3: Cell membrane
Isoform 4: Secreted
Involvement in disease
Severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+) SCID):
A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.
Multiple sclerosis 3 (MS3):
A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheath, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease.
Topology
Extracellular: 21-239
Helical: 240-264
Cytoplasmic: 265-459
PTM
N-glycosylated IL-7Ralpha binds IL7 300-fold more tightly than the unglycosylated form.
More Infomation

Lee, K. Y., Ho, S. C., Sun, W. L., Feng, P. H., Lin, C. W., Chen, K. Y., ... & Wu, S. M. (2022). Lnc-IL7R alleviates PM2. 5-mediated cellular senescence and apoptosis through EZH2 recruitment in chronic obstructive pulmonary disease. Cell Biology and Toxicology, 38(6), 1097-1120.

Oliveira, M. L., Veloso, A., Garcia, E. G., Iyer, S., Pereira, C., Barreto, V. M., ... & Barata, J. T. (2022). Mutant IL7R collaborates with MYC to induce T-cell acute lymphoblastic leukemia. Leukemia, 36(6), 1533-1540.

Wang, X., Chang, S., Wang, T., Wu, R., Huang, Z., Sun, J., ... & Mao, Y. (2022). IL7R is correlated with immune cell infiltration in the tumor microenvironment of lung adenocarcinoma. Frontiers in pharmacology, 13, 857289.

Berna, R., Mitra, N., Lou, C., Wan, J., Hoffstad, O., Wubbenhorst, B., ... & Margolis, D. J. (2021). Thymic stromal lymphopoietin and IL7R variants are associated with persistent atopic dermatitis. The Journal of investigative dermatology, 141(2), 446.

Abdelrasoul, H., Vadakumchery, A., Werner, M., Lenk, L., Khadour, A., Young, M., ... & Jumaa, H. (2020). Synergism between IL7R and CXCR4 drives BCR-ABL induced transformation in Philadelphia chromosome-positive acute lymphoblastic leukemia. Nature Communications, 11(1), 3194.

Kim, R., Boissel, N., Touzart, A., Leguay, T., Thonier, F., Thomas, X., ... & GRAALL group. (2020). Adult T-cell acute lymphoblastic leukemias with IL7R pathway mutations are slow-responders who do not benefit from allogeneic stem-cell transplantation. Leukemia, 34(7), 1730-1740.

Al-Mossawi, H., Yager, N., Taylor, C. A., Lau, E., Danielli, S., de Wit, J., ... & Fairfax, B. P. (2019). Context-specific regulation of surface and soluble IL7R expression by an autoimmune risk allele. Nature Communications, 10(1), 4575.

Leung, G. A., Cool, T., Valencia, C. H., Worthington, A., Beaudin, A. E., & Forsberg, E. C. (2019). The lymphoid-associated interleukin 7 receptor (IL7R) regulates tissue-resident macrophage development. Development, 146(14), dev176180.

Alsadeq, A., Lenk, L., Vadakumchery, A., Cousins, A., Vokuhl, C., Khadour, A., ... & Jumaa, H. (2018). IL7R is associated with CNS infiltration and relapse in pediatric B-cell precursor acute lymphoblastic leukemia. Blood, The Journal of the American Society of Hematology, 132(15), 1614-1617.

Fan, Y., Nan, Y., Huang, J., Zhong, H., & Zhou, W. (2018). Up-regulation of inflammation-related LncRNA-IL7R predicts poor clinical outcome in patients with cervical cancer. Bioscience reports, 38(3), BSR20180483.

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For research use only. Not intended for any clinical use.

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