IGFBP7

This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307).

insulin like growth factor binding protein 7

Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion.

Cell adhesion Source: UniProtKB
Cellular response to hormone stimulus Source: Ensembl
Embryo implantation Source: Ensembl
Negative regulation of cell population proliferation Source: ProtInc
Regulation of cell growth Source: InterPro
Regulation of signal transduction Source: GO_Central
Regulation of steroid biosynthetic process Source: Ensembl
Response to cortisol Source: Ensembl
Response to heat Source: Ensembl
Response to retinoic acid Source: Ensembl

Secreted

Retinal arterial macroaneurysm with supravalvular pulmonic stenosis (RAMSVPS):
An autosomal recessive condition characterized by the bilateral appearance of 'beading' along the major retinal arterial trunks, with the subsequent formation of macroaneurysms. Affected individuals also have supravalvular pulmonic stenosis, often requiring surgical correction.

N-glycosylated.