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Mouse Anti-IGFBP7 Recombinant Antibody (CBXF-1376) (CBMAB-F1308-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-1376
Antibody Isotype
IgG1
Application
ELISA

Basic Information

Immunogen
Recombinant Human IGFBP7 protein
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
insulin like growth factor binding protein 7
Introduction
This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307).
Entrez Gene ID
3490
UniProt ID
Q16270
Alternative Names
Insulin Like Growth Factor Binding Protein 7
Function
Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion.
Biological Process
Cell adhesion Source: UniProtKB
Cellular response to hormone stimulus Source: Ensembl
Embryo implantation Source: Ensembl
Negative regulation of cell population proliferation Source: ProtInc
Regulation of cell growth Source: InterPro
Regulation of signal transduction Source: GO_Central
Regulation of steroid biosynthetic process Source: Ensembl
Response to cortisol Source: Ensembl
Response to heat Source: Ensembl
Response to retinoic acid Source: Ensembl
Cellular Location
Secreted
Involvement in disease
Retinal arterial macroaneurysm with supravalvular pulmonic stenosis (RAMSVPS):
An autosomal recessive condition characterized by the bilateral appearance of 'beading' along the major retinal arterial trunks, with the subsequent formation of macroaneurysms. Affected individuals also have supravalvular pulmonic stenosis, often requiring surgical correction.
PTM
N-glycosylated.
More Infomation

Yi, X., Zheng, X., Xu, H., Li, J., Zhang, T., Ge, P., ... & Ai, J. (2022). IGFBP7 and the tumor immune landscape: a novel target for immunotherapy in bladder cancer. Frontiers in Immunology, 13, 898493.

Ko, T., Nomura, S., Yamada, S., Fujita, K., Fujita, T., Satoh, M., ... & Komuro, I. (2022). Cardiac fibroblasts regulate the development of heart failure via Htra3-TGF-β-IGFBP7 axis. Nature communications, 13(1), 3275.

Zhao, Q., Zhao, R., Song, C., Wang, H., Rong, J., Wang, F., ... & Xie, Y. (2021). Increased IGFBP7 expression correlates with poor prognosis and immune infiltration in gastric cancer. Journal of Cancer, 12(5), 1343.

Jin, L., Shen, F., Weinfeld, M., & Sergi, C. (2020). Insulin growth factor binding protein 7 (IGFBP7)-related cancer and IGFBP3 and IGFBP7 crosstalk. Frontiers in Oncology, 10, 727.

Huang, X., Hong, C., Peng, Y., Yang, S., Huang, L., Liu, C., ... & Xu, Y. (2019). The diagnostic value of serum IGFBP7 in patients with esophageal squamous cell carcinoma. Journal of Cancer, 10(12), 2687.

Fejzo, M. S., Fasching, P. A., Schneider, M. O., Schwitulla, J., Beckmann, M. W., Schwenke, E., ... & Mullin, P. M. (2019). Analysis of GDF15 and IGFBP7 in hyperemesis gravidarum support causality. Geburtshilfe und Frauenheilkunde, 79(04), 382-388.

Zhang, L., Lian, R., Zhao, J., Feng, X., Ye, R., Pan, L., ... & Cai, J. (2019). IGFBP7 inhibits cell proliferation by suppressing AKT activity and cell cycle progression in thyroid carcinoma. Cell & bioscience, 9(1), 1-13.

Fejzo, M. S., Sazonova, O. V., Sathirapongsasuti, J. F., Hallgrímsdóttir, I. B., Vacic, V., MacGibbon, K. W., ... & Mullin, P. M. (2018). Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum. Nature communications, 9(1), 1178.

Johnson, A. C., & Zager, R. A. (2018). Mechanisms underlying increased TIMP2 and IGFBP7 urinary excretion in experimental AKI. Journal of the American Society of Nephrology: JASN, 29(8), 2157.

Januzzi Jr, J. L., Packer, M., Claggett, B., Liu, J., Shah, A. M., Zile, M. R., ... & Solomon, S. D. (2018). IGFBP7 (insulin-like growth factor–binding protein-7) and neprilysin inhibition in patients with heart failure. Circulation: Heart Failure, 11(10), e005133.

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For research use only. Not intended for any clinical use.

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