IGF2BP2

This gene encodes a protein that binds the 5' UTR of insulin-like growth factor 2 (IGF2) mRNA and regulates its translation. It plays an important role in metabolism and variation in this gene is associated with susceptibility to diabetes. Alternative splicing and promoter usage results in multiple transcript variants. Related pseudogenes are found on several chromosomes. [provided by RefSeq, Sep 2016]

Full Name

Insulin Like Growth Factor 2 MRNA Binding Protein 2

Function

RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity).

Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts.

Biological Process

Anatomical structure morphogenesis Source: ProtInc
mRNA transport Source: UniProtKB-KW
Negative regulation of translation Source: BHF-UCL
Nervous system development Source: GO_Central
Regulation of cytokine production Source: BHF-UCL
Regulation of gene expression Source: GO_Central
Regulation of RNA metabolic process Source: GO_Central

Cellular Location

Cytoplasm; Nucleus. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Localizes at the connecting piece and the tail of the spermatozoa. In response to cellular stress, such as oxidative stress, recruited to stress granules.

Anti-IGF2BP2 antibodies

Mouse Anti-IGF2BP2 Recombinant Antibody (CBYY-I1938) (CBMAB-I3108-YY)

Datasheet

SDS

Target: IGF2BP2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Dog, Monkey

Clone: CBYY-I1938

Application*: WB, IH, IF, F

Mouse Anti-IGF2BP2 Recombinant Antibody (CBYY-I2007) (CBMAB-I3177-YY)

Datasheet

SDS

Target: IGF2BP2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Monkey

Clone: CBYY-I2007

Application*: WB, IF, F

Mouse Anti-IGF2BP2 Recombinant Antibody (CBYY-I2073) (CBMAB-I3243-YY)

Datasheet

SDS

Target: IGF2BP2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Monkey

Clone: CBYY-I2073

Application*: IF, F

Mouse Anti-IGF2BP2 Recombinant Antibody (CBYY-I2110) (CBMAB-I3280-YY)

Datasheet

SDS

Target: IGF2BP2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Monkey

Clone: CBYY-I2110

Application*: WB, IF

Mouse Anti-IGF2BP2 Recombinant Antibody (4C6) (CBMAB-A4297-LY)

Datasheet

SDS

Target: IGF2BP2

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 4C6

Application*: WB, E

Rabbit Anti-IGF2BP2 Recombinant Antibody (EG1617) (CBMAB-EN1934-LY)

Datasheet

SDS

Target: IGF2BP2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: EG1617

Application*: WB: 1:500~1:1000 ELISA: 1:20000

Mouse Anti-IGF2BP2 Recombinant Antibody (4C4) (CBMAB-I1316-YY)

Datasheet

SDS

Target: IGF2BP2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Dog, Monkey

Clone: 4C4

Application*: F, IF, IH, P, WB

Mouse Anti-IGF2BP2 Recombinant Antibody (CBYY-I0601) (CBMAB-I1318-YY)

Datasheet

SDS

Target: IGF2BP2

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBYY-I0601

Application*: E, IP, WB

Mouse Anti-IGF2BP2 Recombinant Antibody (4D10) (CBMAB-I1321-YY)

Datasheet

SDS

Target: IGF2BP2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Monkey

Clone: 4D10

Application*: WB, F, IF

Mouse Anti-IGF2BP2 Recombinant Antibody (5G3) (CBMAB-I1448-YY)

Datasheet

SDS

Target: IGF2BP2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Monkey

Clone: 5G3

Application*: F, IF, IH, P, WB

Mouse Anti-IGF2BP2 Recombinant Antibody (6C4) (CBMAB-I1555-YY)

Datasheet

SDS

Target: IGF2BP2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Monkey

Clone: 6C4

Application*: IF, WB

Mouse Anti-IGF2BP2 Recombinant Antibody (CBYY-I0929) (CBMAB-I2097-YY)

Datasheet

SDS

Target: IGF2BP2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-I0929

Application*: F, IF, WB

IGF2BP2 Matched Antibody Pair (606) (APMAB-606LY)

Datasheet

SDS

Target: IGF2BP2

Specificity: Human

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)