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IGF2BP2 Matched Antibody Pair (606) (APMAB-606LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-IGF2BP2 polyclonal antibody, 100 ug
Detection Antibody
Anti-IGF2BP2 Mouse polyclonal antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes a protein that binds the 5' UTR of insulin-like growth factor 2 (IGF2) mRNA and regulates its translation. It plays an important role in metabolism and variation in this gene is associated with susceptibility to diabetes. Alternative splicing and promoter usage results in multiple transcript variants. Related pseudogenes are found on several chromosomes. [provided by RefSeq, Sep 2016]
Alternative Names
Insulin Like Growth Factor 2 MRNA Binding Protein 2
Entrez Gene ID
10644
UniProt ID
Q9Y6M1
More Infomation

Yang, J., Qian, X., Qiu, Q., Xu, L., Pan, M., Li, J., ... & Liu, P. (2022). LCAT1 is an oncogenic LncRNA by stabilizing the IGF2BP2-CDC6 axis. Cell Death & Disease, 13(10), 877.

Weng, H., Huang, F., Yu, Z., Chen, Z., Prince, E., Kang, Y., ... & Chen, J. (2022). The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia. Cancer cell, 40(12), 1566-1582.

Suo, M., Rommelfanger, M. K., Chen, Y., Amro, E. M., Han, B., Chen, Z., ... & Rudolph, K. L. (2022). Age-dependent effects of Igf2bp2 on gene regulation, function, and aging of hematopoietic stem cells in mice. Blood, The Journal of the American Society of Hematology, 139(17), 2653-2665.

Wang, J., Chen, L., & Qiang, P. (2021). The role of IGF2BP2, an m6A reader gene, in human metabolic diseases and cancers. Cancer Cell International, 21(1), 99.

Dai, N. (2020). The diverse functions of IMP2/IGF2BP2 in metabolism. Trends in Endocrinology & Metabolism, 31(9), 670-679.

Hu, X., Peng, W. X., Zhou, H., Jiang, J., Zhou, X., Huang, D., ... & Yang, L. (2020). IGF2BP2 regulates DANCR by serving as an N6-methyladenosine reader. Cell Death & Differentiation, 27(6), 1782-1794.

Wang, Y., Lu, J. H., Wu, Q. N., Jin, Y., Wang, D. S., Chen, Y. X., ... & Xu, R. H. (2019). LncRNA LINRIS stabilizes IGF2BP2 and promotes the aerobic glycolysis in colorectal cancer. Molecular cancer, 18(1), 1-18.

Li, T., Hu, P. S., Zuo, Z., Lin, J. F., Li, X., Wu, Q. N., ... & Xu, R. H. (2019). METTL3 facilitates tumor progression via an m6A-IGF2BP2-dependent mechanism in colorectal carcinoma. Molecular cancer, 18(1), 1-15.

Xu, X., Yu, Y., Zong, K., Lv, P., & Gu, Y. (2019). Up-regulation of IGF2BP2 by multiple mechanisms in pancreatic cancer promotes cancer proliferation by activating the PI3K/Akt signaling pathway. Journal of Experimental & Clinical Cancer Research, 38(1), 1-14.

He, X., Li, W., Liang, X., Zhu, X., Zhang, L., Huang, Y., ... & Chen, Z. (2018). IGF2BP2 overexpression indicates poor survival in patients with acute myelocytic leukemia. Cellular Physiology and Biochemistry, 51(4), 1945-1956.

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For research use only. Not intended for any clinical use.

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