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Mouse Anti-IGF2BP2 Recombinant Antibody (4C6) (CBMAB-A4297-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
4C6
Antibody Isotype
IgG2b, κ
Application
WB, ELISA

Basic Information

Immunogen
IGF2BP2 (AAH21290, 1 a.a. ~ 598 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Insulin Like Growth Factor 2 MRNA Binding Protein 2
Introduction
This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains several four KH domains and two RRM domains. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]
Entrez Gene ID
10644
UniProt ID
Q9Y6M1
Alternative Names
IMP-2; IMP2; VICKZ2; p62
Function
RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity).

Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts.
Biological Process
Anatomical structure morphogenesis Source: ProtInc
mRNA transport Source: UniProtKB-KW
Negative regulation of translation Source: BHF-UCL
Nervous system development Source: GO_Central
Regulation of cytokine production Source: BHF-UCL
Regulation of gene expression Source: GO_Central
Regulation of RNA metabolic process Source: GO_Central
Cellular Location
Cytoplasm; Nucleus. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Localizes at the connecting piece and the tail of the spermatozoa. In response to cellular stress, such as oxidative stress, recruited to stress granules.
More Infomation

Yang, J., Qian, X., Qiu, Q., Xu, L., Pan, M., Li, J., ... & Liu, P. (2022). LCAT1 is an oncogenic LncRNA by stabilizing the IGF2BP2-CDC6 axis. Cell Death & Disease, 13(10), 877.

Weng, H., Huang, F., Yu, Z., Chen, Z., Prince, E., Kang, Y., ... & Chen, J. (2022). The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia. Cancer cell, 40(12), 1566-1582.

Suo, M., Rommelfanger, M. K., Chen, Y., Amro, E. M., Han, B., Chen, Z., ... & Rudolph, K. L. (2022). Age-dependent effects of Igf2bp2 on gene regulation, function, and aging of hematopoietic stem cells in mice. Blood, The Journal of the American Society of Hematology, 139(17), 2653-2665.

Wang, J., Chen, L., & Qiang, P. (2021). The role of IGF2BP2, an m6A reader gene, in human metabolic diseases and cancers. Cancer Cell International, 21(1), 99.

Dai, N. (2020). The diverse functions of IMP2/IGF2BP2 in metabolism. Trends in Endocrinology & Metabolism, 31(9), 670-679.

Hu, X., Peng, W. X., Zhou, H., Jiang, J., Zhou, X., Huang, D., ... & Yang, L. (2020). IGF2BP2 regulates DANCR by serving as an N6-methyladenosine reader. Cell Death & Differentiation, 27(6), 1782-1794.

Wang, Y., Lu, J. H., Wu, Q. N., Jin, Y., Wang, D. S., Chen, Y. X., ... & Xu, R. H. (2019). LncRNA LINRIS stabilizes IGF2BP2 and promotes the aerobic glycolysis in colorectal cancer. Molecular cancer, 18(1), 1-18.

Li, T., Hu, P. S., Zuo, Z., Lin, J. F., Li, X., Wu, Q. N., ... & Xu, R. H. (2019). METTL3 facilitates tumor progression via an m6A-IGF2BP2-dependent mechanism in colorectal carcinoma. Molecular cancer, 18(1), 1-15.

Xu, X., Yu, Y., Zong, K., Lv, P., & Gu, Y. (2019). Up-regulation of IGF2BP2 by multiple mechanisms in pancreatic cancer promotes cancer proliferation by activating the PI3K/Akt signaling pathway. Journal of Experimental & Clinical Cancer Research, 38(1), 1-14.

He, X., Li, W., Liang, X., Zhu, X., Zhang, L., Huang, Y., ... & Chen, Z. (2018). IGF2BP2 overexpression indicates poor survival in patients with acute myelocytic leukemia. Cellular Physiology and Biochemistry, 51(4), 1945-1956.

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For research use only. Not intended for any clinical use.

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