ID3

The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with other HLH proteins. However, the encoded protein lacks a basic DNA-binding domain and therefore inhibits the DNA binding of any HLH protein with which it interacts. [provided by RefSeq, Aug 2011]

ID3

Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer.

Cell differentiation Source: GO_Central
Cellular response to leptomycin B Source: Ensembl
Central nervous system development Source: Ensembl
Circadian regulation of gene expression Source: GO_Central
Epithelial cell differentiation Source: Ensembl
Heart development Source: Ensembl
Metanephros development Source: Ensembl
Multicellular organism development Source: ProtInc
Muscle organ development Source: UniProtKB-KW
Negative regulation of DNA-binding transcription factor activity Source: GDB
Negative regulation of gene expression Source: Ensembl
Negative regulation of myoblast differentiation Source: Ensembl
Negative regulation of osteoblast differentiation Source: Ensembl
Negative regulation of transcription, DNA-templated Source: GDB
Negative regulation of transcription by RNA polymerase II Source: GO_Central
Neuron differentiation Source: Ensembl
Notochord development Source: Ensembl
Odontogenesis Source: Ensembl
Positive regulation of apoptotic process Source: Ensembl
Positive regulation of gene expression Source: Ensembl
Regulation of cell cycle Source: Ensembl
Regulation of DNA replication Source: Ensembl
Response to wounding Source: Ensembl

Nucleus