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Mouse Anti-ID3 Recombinant Antibody (CBYY-I1568) (CBMAB-I2738-YY)


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Summary

Host Animal
Mouse
Specificity
Mouse
Clone
CBYY-I1568
Antibody Isotype
IgG1, κ
Application
WB

Basic Information

Specificity
Mouse
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
0.5 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ID3
Introduction
The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with other HLH proteins. However, the encoded protein lacks a basic DNA-binding domain and therefore inhibits the DNA binding of any HLH protein with which it interacts.
Entrez Gene ID
15903
UniProt ID
P41133
Alternative Names
Inhibitor Of DNA Binding 3, HLH Protein
Function
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer.
Biological Process
Cell differentiation Source: GO_Central
Cellular response to leptomycin B Source: Ensembl
Central nervous system development Source: Ensembl
Circadian regulation of gene expression Source: GO_Central
Epithelial cell differentiation Source: Ensembl
Heart development Source: Ensembl
Metanephros development Source: Ensembl
Multicellular organism development Source: ProtInc
Muscle organ development Source: UniProtKB-KW
Negative regulation of DNA-binding transcription factor activity Source: GDB
Negative regulation of gene expression Source: Ensembl
Negative regulation of myoblast differentiation Source: Ensembl
Negative regulation of osteoblast differentiation Source: Ensembl
Negative regulation of transcription, DNA-templated Source: GDB
Negative regulation of transcription by RNA polymerase II Source: GO_Central
Neuron differentiation Source: Ensembl
Notochord development Source: Ensembl
Odontogenesis Source: Ensembl
Positive regulation of apoptotic process Source: Ensembl
Positive regulation of gene expression Source: Ensembl
Regulation of cell cycle Source: Ensembl
Regulation of DNA replication Source: Ensembl
Response to wounding Source: Ensembl
Cellular Location
Nucleus
More Infomation

Xu, J., Dominguez, M. P., & Alewine, C. (2022). Loss of ID3 in pancreatic cancer cells increases DNA damage without impairing MDC1 recruitment to the nuclear foci. Cancer Communications, 42(3), 269.

Fang, L., Gao, Y., Wang, Z., Li, Y., Yan, Y., Wu, Z., ... & Sun, Y. P. (2021). EGF stimulates human trophoblast cell invasion by downregulating ID3-mediated KISS1 expression. Cell Communication and Signaling, 19, 1-13.

Liu, C., Zeng, X., Yu, S., Ren, L., Sun, X., Long, Y., ... & Zhang, Y. (2021). Up-regulated DNA-binding inhibitor Id3 promotes differentiation of regulatory T cell to influence antiviral immunity in chronic hepatitis B virus infection. Life Sciences, 285, 119991.

Bakr, A., Hey, J., Sigismondo, G., Liu, C. S., Sadik, A., Goyal, A., ... & Schmezer, P. (2021). ID3 promotes homologous recombination via non-transcriptional and transcriptional mechanisms and its loss confers sensitivity to PARP inhibition. Nucleic acids research, 49(20), 11666-11689.

Wang, Z., Nan, W., Si, H., Wang, S., Zhang, H., & Li, G. (2020). Pantothenic acid promotes dermal papilla cell proliferation in hair follicles of American minks via inhibitor of DNA Binding 3/Notch signaling pathway. Life sciences, 252, 117667.

Liu, C., Yu, S., Jin, R., Long, Y., Lu, S., Song, Y., ... & Zhang, Y. (2020). Correlation of the levels of DNA-binding inhibitor Id3 and regulatory T cells with SLE disease severity. Journal of Autoimmunity, 113, 102498.

Han, X., Liu, H., Huang, H., Liu, X., Jia, B., Gao, G. F., & Zhang, F. (2019). ID2 and ID3 are indispensable for Th1 cell differentiation during influenza virus infection in mice. European Journal of Immunology, 49(3), 476-489.

Topno, N. S., Kannan, M., & Krishna, R. (2018). Mechanistic insights into the activity of Ptf1-p48 (pancreas transcription factor 1a): probing the interactions levels of Ptf1-p48 with E2A-E47 (transcription factor E2-alpha) and ID3 (inhibitor of DNA binding 3). Journal of Biomolecular Structure and Dynamics, 36(7), 1834-1852.

Han, J., Seo, H., Choi, Y., Lee, C., Kim, M. I., Jeon, Y., ... & Ka, H. (2018). Expression and regulation of inhibitor of DNA binding proteins ID1, ID2, ID3, and ID4 at the maternal-conceptus interface in pigs. Theriogenology, 108, 46-55.

Chen, F. F., Lv, X., Zhao, Q. F., Xu, Y. Z., Song, S. S., Yu, W., & Li, X. J. (2018). Inhibitor of DNA binding 3 reverses cisplatin resistance in human lung adenocarcinoma cells by regulating the PI3K/Akt pathway. Oncology letters, 16(2), 1634-1640.

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For research use only. Not intended for any clinical use.

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