HTR4

This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described.

5-hydroxytryptamine receptor 4

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.

Adenylate cyclase-inhibiting serotonin receptor signaling pathway Source: GO_Central
Chemical synaptic transmission Source: GO_Central
G protein-coupled receptor signaling pathway Source: ProtInc
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
Regulation of appetite Source: InterPro

Cell membrane; Endosome. Interaction with SNX27 mediates recruitment to early endosomes, while interaction with SLC9A3R1 and EZR might target the protein to specialized subcellular regions, such as microvilli.

Extracellular: 1-19
Helical: 20-40
Cytoplasmic: 41-58
Helical: 59-79
Extracellular: 80-93
Helical: 94-116
Cytoplasmic: 117-137
Helical: 138-158
Extracellular: 159-192
Helical: 193-213
Cytoplasmic: 214-260
Helical: 261-281
Extracellular: 282-294
Helical: 295-315
Cytoplasmic: 316-388