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Mouse Anti-HTR4 Recombinant Antibody (CBXS-2407) (CBMAB-S5164-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-2407
Antibody Isotype
IgG2b
Application
IHC

Basic Information

Immunogen
Recombinant corresponding to human HTR4 expressed in NSO cells
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
5-hydroxytryptamine receptor 4
Introduction
This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described.
Entrez Gene ID
3360
UniProt ID
Q13639
Alternative Names
5-Hydroxytryptamine Receptor 4; 5-Hydroxytryptamine (Serotonin) Receptor 4, G Protein-Coupled; 5-HT4; 5-Hydroxytryptamine Receptor 4 Transcript Variant B2; 5-Hydroxytryptamine Receptor 4 Transcript Variant B3; 5-Hydroxytryptamine (Serotonin) Receptor 4;
Function
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.
Biological Process
Adenylate cyclase-inhibiting serotonin receptor signaling pathway Source: GO_Central
Chemical synaptic transmission Source: GO_Central
G protein-coupled receptor signaling pathway Source: ProtInc
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
Regulation of appetite Source: InterPro
Cellular Location
Cell membrane; Endosome. Interaction with SNX27 mediates recruitment to early endosomes, while interaction with SLC9A3R1 and EZR might target the protein to specialized subcellular regions, such as microvilli.
Topology
Extracellular: 1-19
Helical: 20-40
Cytoplasmic: 41-58
Helical: 59-79
Extracellular: 80-93
Helical: 94-116
Cytoplasmic: 117-137
Helical: 138-158
Extracellular: 159-192
Helical: 193-213
Cytoplasmic: 214-260
Helical: 261-281
Extracellular: 282-294
Helical: 295-315
Cytoplasmic: 316-388
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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