HSV-2 gD

Alphaherpesvirinae is a subfamily of Herpesviridae, primarily distinguished by reproducing more quickly than other subfamilies of Herpesviridae. In animal virology the most important herpesviruses belong to the Alphaherpesvirinae. Pseudorabies virus is the causative agent of Aujeszky's disease in pigs and bovine herpesvirus 1 is the causative agent of bovine infectious rhinotracheitis and pustular vulvovaginitis. Mammals serve as natural hosts. There are currently 37 species in this subfamily, divided among 5 genera. Diseases associated with this subfamily include: HHV-1 and HHV-2: skin vesicles or mucosal ulcers, rarely encephalitis and meningitis HHV-3: chickenpox (varicella) and shingles gaHV-2: Marek's disease.

Human Herpesvirus 2 Glycoprotein D

Envelope glycoprotein that binds to the potential host cell entry receptors TNFRSF14/HVEM and NECTIN1. May trigger fusion with host membrane, by recruiting the fusion machinery composed of gB and gH/gL (By similarity).

Coreceptor-mediated virion attachment to host cell Source: BHF-UCL
Entry receptor-mediated virion attachment to host cell Source: UniProtKB-KW
Fusion of virus membrane with host plasma membrane Source: BHF-UCL

Virion membrane. During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs.

Virion surface: 26-339
Helical: 340-363
Intravirion: 364-393