HPN

This gene encodes a type II transmembrane serine protease that may be involved in diverse cellular functions, including blood coagulation and the maintenance of cell morphology. Expression of the encoded protein is associated with the growth and progression of cancers, particularly prostate cancer. The protein is cleaved into a catalytic serine protease chain and a non-catalytic scavenger receptor cysteine-rich chain, which associate via a single disulfide bond. Alternative splicing results in multiple transcript variants.

hepsin

Hepsin; Transmembrane Protease Serine 1; EC 3.4.21.106; TMPRSS1; Transmembrane Protease, Serine 1; Testicular Tissue Protein Li 85; Serine Protease Hepsin; EC 3.4.2

Serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL (PubMed:21875933, PubMed:15839837).

Plays a role in cell growth and maintenance of cell morphology (PubMed:8346233, PubMed:21875933).

Plays a role in the proteolytic processing of ACE2 (PubMed:24227843).

Mediates the proteolytic cleavage of urinary UMOD that is required for UMOD polymerization (PubMed:26673890).

Basement membrane disassembly Source: UniProtKB
Cochlea morphogenesis Source: UniProtKB
Detection of mechanical stimulus involved in sensory perception of sound Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of epithelial cell proliferation Source: UniProtKB
Negative regulation of epithelial to mesenchymal transition Source: UniProtKB
Pilomotor reflex Source: UniProtKB
Positive regulation by host of viral transcription Source: UniProtKB
Positive regulation of cell growth Source: UniProtKB
Positive regulation of gene expression Source: UniProtKB
Positive regulation of hepatocyte proliferation Source: UniProtKB
Positive regulation of plasminogen activation Source: UniProtKB
Positive regulation of thyroid hormone generation Source: UniProtKB
Potassium ion transmembrane transport Source: UniProtKB
Proteolysis Source: UniProtKB
Regulation of cell shape Source: UniProtKB
Response to thyroid hormone Source: UniProtKB

Cell membrane; Apical cell membrane

Cytoplasmic: 1-23
Helical: 24-44
Extracellular: 45-417