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Mouse Anti-HPN Recombinant Antibody (CBFYH-1901) (CBMAB-H2907-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-1901
Antibody Isotype
IgG1
Application
IHC

Basic Information

Immunogen
Mouse myeloma cell line NS0-derived recombinant human Hepsin, Ser46-Leu417
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
hepsin
Introduction
This gene encodes a type II transmembrane serine protease that may be involved in diverse cellular functions, including blood coagulation and the maintenance of cell morphology. Expression of the encoded protein is associated with the growth and progression of cancers, particularly prostate cancer. The protein is cleaved into a catalytic serine protease chain and a non-catalytic scavenger receptor cysteine-rich chain, which associate via a single disulfide bond. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
3249
UniProt ID
P05981
Alternative Names
Hepsin; Transmembrane Protease Serine 1; EC 3.4.21.106; TMPRSS1; Transmembrane Protease, Serine 1; Testicular Tissue Protein Li 85; Serine Protease Hepsin; EC 3.4.2
Function
Serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL (PubMed:21875933, PubMed:15839837).

Plays a role in cell growth and maintenance of cell morphology (PubMed:8346233, PubMed:21875933).

Plays a role in the proteolytic processing of ACE2 (PubMed:24227843).

Mediates the proteolytic cleavage of urinary UMOD that is required for UMOD polymerization (PubMed:26673890).
Biological Process
Basement membrane disassembly Source: UniProtKB
Cochlea morphogenesis Source: UniProtKB
Detection of mechanical stimulus involved in sensory perception of sound Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of epithelial cell proliferation Source: UniProtKB
Negative regulation of epithelial to mesenchymal transition Source: UniProtKB
Pilomotor reflex Source: UniProtKB
Positive regulation by host of viral transcription Source: UniProtKB
Positive regulation of cell growth Source: UniProtKB
Positive regulation of gene expression Source: UniProtKB
Positive regulation of hepatocyte proliferation Source: UniProtKB
Positive regulation of plasminogen activation Source: UniProtKB
Positive regulation of thyroid hormone generation Source: UniProtKB
Potassium ion transmembrane transport Source: UniProtKB
Proteolysis Source: UniProtKB
Regulation of cell shape Source: UniProtKB
Response to thyroid hormone Source: UniProtKB
Cellular Location
Cell membrane; Apical cell membrane
Topology
Cytoplasmic: 1-23
Helical: 24-44
Extracellular: 45-417
More Infomation

Zaragoza-Huesca, D., Nieto-Olivares, A., García-Molina, F., Ricote, G., Montenegro, S., Sánchez-Cánovas, M., ... & Martínez-Martínez, I. (2022). Implication of Hepsin from primary tumor in the prognosis of colorectal cancer patients. Cancers, 14(13), 3106.

Rodenas, M. C., Peñas-Martínez, J., Pardo-Sánchez, I., Zaragoza-Huesca, D., Ortega-Sabater, C., Peña-García, J., ... & Martínez-Martínez, I. (2023). Venetoclax is a potent hepsin inhibitor that reduces the metastatic and prothrombotic phenotypes of hepsin-expressing colorectal cancer cells. Frontiers in Molecular Biosciences, 10, 1182925.

Fang, Y., Yang, H., Hu, G., Lu, J., Zhou, J., Gao, N., ... & Qiao, H. (2022). The POR rs10954732 polymorphism decreases susceptibility to hepatocellular carcinoma and hepsin as a prognostic biomarker correlated with immune infiltration based on proteomics. Journal of translational medicine, 20(1), 1-17.

Lu, L., Cole, A., Huang, D., Wang, Q., Guo, Z., Yang, W., & Lu, J. (2022). Clinical significance of hepsin and underlying signaling pathways in prostate cancer. Biomolecules, 12(2), 203.

Li, S., Wang, L., Sun, S., & Wu, Q. (2021). Hepsin: a multifunctional transmembrane serine protease in pathobiology. The FEBS journal, 288(18), 5252-5264.

Li, S., Peng, J., Wang, H., Zhang, W., Brown, J. M., Zhou, Y., & Wu, Q. (2020). Hepsin enhances liver metabolism and inhibits adipocyte browning in mice. Proceedings of the National Academy of Sciences, 117(22), 12359-12367.

Tieng, F. Y. F., Abu, N., Sukor, S., Mohd Azman, Z. A., Mahamad Nadzir, N., Lee, L. H., & Ab Mutalib, N. S. (2020). L1CAM, CA9, KLK6, HPN, and ALDH1A1 as potential serum markers in primary and metastatic colorectal cancer screening. Diagnostics, 10(7), 444.

Willbold, R., Wirth, K., Martini, T., Sültmann, H., Bolenz, C., & Wittig, R. (2019). Excess hepsin proteolytic activity limits oncogenic signaling and induces ER stress and autophagy in prostate cancer cells. Cell Death & Disease, 10(8), 601.

Olinger, E., Lake, J., Sheehan, S., Schiano, G., Takata, T., Tokonami, N., ... & Devuyst, O. (2019). Hepsin-mediated processing of uromodulin is crucial for salt-sensitivity and thick ascending limb homeostasis. Scientific reports, 9(1), 12287.

Lee, S. G., Kim, C. H., Sung, S. W., Lee, E. S., Goh, M. S., Yoon, H. Y., ... & Choi, Y. W. (2018). RIPL peptide-conjugated nanostructured lipid carriers for enhanced intracellular drug delivery to hepsin-expressing cancer cells. International journal of nanomedicine, 3263-3278.

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For research use only. Not intended for any clinical use.

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