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Mouse Anti-HPN Recombinant Antibody (AG84) (V2LY-0524-LY43)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
AG84
Antibody Isotype
IgG1, κ
Application
ELISA, FC

Basic Information

Immunogen
Human hepsin protein
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Endotoxin
< 1.0 EU/mg as determined by the LAL method
Format
Liquid
Buffer
PBS
Preservative
None
Concentration
5 mg/ml
Purity
>95% by SDS Page
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
hepsin
Entrez Gene ID
3249
UniProt ID
P05981
Alternative Names
Hepsin; Transmembrane Protease Serine 1; EC 3.4.21.106; TMPRSS1; Transmembrane Protease, Serine 1; Testicular Tissue Protein Li 85; Serine Protease Hepsin; EC 3.4.2
Function
Serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL (PubMed:21875933, PubMed:15839837).

Plays a role in cell growth and maintenance of cell morphology (PubMed:8346233, PubMed:21875933).

Plays a role in the proteolytic processing of ACE2 (PubMed:24227843).

Mediates the proteolytic cleavage of urinary UMOD that is required for UMOD polymerization (PubMed:26673890).
Biological Process
Basement membrane disassembly Source: UniProtKB
Cochlea morphogenesis Source: UniProtKB
Detection of mechanical stimulus involved in sensory perception of sound Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of epithelial cell proliferation Source: UniProtKB
Negative regulation of epithelial to mesenchymal transition Source: UniProtKB
Pilomotor reflex Source: UniProtKB
Positive regulation by host of viral transcription Source: UniProtKB
Positive regulation of cell growth Source: UniProtKB
Positive regulation of gene expression Source: UniProtKB
Positive regulation of hepatocyte proliferation Source: UniProtKB
Positive regulation of plasminogen activation Source: UniProtKB
Positive regulation of thyroid hormone generation Source: UniProtKB
Potassium ion transmembrane transport Source: UniProtKB
Proteolysis Source: UniProtKB
Regulation of cell shape Source: UniProtKB
Response to thyroid hormone Source: UniProtKB
Cellular Location
Cell membrane; Apical cell membrane
Topology
Cytoplasmic: 1-23
Helical: 24-44
Extracellular: 45-417
More Infomation

Zaragoza-Huesca, D., Nieto-Olivares, A., García-Molina, F., Ricote, G., Montenegro, S., Sánchez-Cánovas, M., ... & Martínez-Martínez, I. (2022). Implication of Hepsin from primary tumor in the prognosis of colorectal cancer patients. Cancers, 14(13), 3106.

Rodenas, M. C., Peñas-Martínez, J., Pardo-Sánchez, I., Zaragoza-Huesca, D., Ortega-Sabater, C., Peña-García, J., ... & Martínez-Martínez, I. (2023). Venetoclax is a potent hepsin inhibitor that reduces the metastatic and prothrombotic phenotypes of hepsin-expressing colorectal cancer cells. Frontiers in Molecular Biosciences, 10, 1182925.

Fang, Y., Yang, H., Hu, G., Lu, J., Zhou, J., Gao, N., ... & Qiao, H. (2022). The POR rs10954732 polymorphism decreases susceptibility to hepatocellular carcinoma and hepsin as a prognostic biomarker correlated with immune infiltration based on proteomics. Journal of translational medicine, 20(1), 1-17.

Lu, L., Cole, A., Huang, D., Wang, Q., Guo, Z., Yang, W., & Lu, J. (2022). Clinical significance of hepsin and underlying signaling pathways in prostate cancer. Biomolecules, 12(2), 203.

Li, S., Wang, L., Sun, S., & Wu, Q. (2021). Hepsin: a multifunctional transmembrane serine protease in pathobiology. The FEBS journal, 288(18), 5252-5264.

Li, S., Peng, J., Wang, H., Zhang, W., Brown, J. M., Zhou, Y., & Wu, Q. (2020). Hepsin enhances liver metabolism and inhibits adipocyte browning in mice. Proceedings of the National Academy of Sciences, 117(22), 12359-12367.

Tieng, F. Y. F., Abu, N., Sukor, S., Mohd Azman, Z. A., Mahamad Nadzir, N., Lee, L. H., & Ab Mutalib, N. S. (2020). L1CAM, CA9, KLK6, HPN, and ALDH1A1 as potential serum markers in primary and metastatic colorectal cancer screening. Diagnostics, 10(7), 444.

Willbold, R., Wirth, K., Martini, T., Sültmann, H., Bolenz, C., & Wittig, R. (2019). Excess hepsin proteolytic activity limits oncogenic signaling and induces ER stress and autophagy in prostate cancer cells. Cell Death & Disease, 10(8), 601.

Olinger, E., Lake, J., Sheehan, S., Schiano, G., Takata, T., Tokonami, N., ... & Devuyst, O. (2019). Hepsin-mediated processing of uromodulin is crucial for salt-sensitivity and thick ascending limb homeostasis. Scientific reports, 9(1), 12287.

Lee, S. G., Kim, C. H., Sung, S. W., Lee, E. S., Goh, M. S., Yoon, H. Y., ... & Choi, Y. W. (2018). RIPL peptide-conjugated nanostructured lipid carriers for enhanced intracellular drug delivery to hepsin-expressing cancer cells. International journal of nanomedicine, 3263-3278.

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For research use only. Not intended for any clinical use.

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