HOP Homeobox is a homeodomain protein that lacks certain conserved residues required for DNA binding. Studies in mice suggest that HOP Homeobox may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene expression and cardiac development.
Full Name
HOPX
Function
Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity).
May act as a tumor suppressor. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding (PubMed:27708256).
Biological Process
Bundle of His development Source: BHF-UCL Chaperone-mediated protein complex assembly Source: CAFA Histone deacetylation Source: Ensembl Lung alveolus development Source: Ensembl Negative regulation of cell differentiation Source: MGI Negative regulation of transcription by RNA polymerase II Source: Ensembl Positive regulation of skeletal muscle tissue regeneration Source: Ensembl Positive regulation of striated muscle cell differentiation Source: Ensembl Regulation of heart contraction Source: Ensembl Regulation of protein binding Source: Ensembl Regulation of transcription by RNA polymerase II Source: GO_Central Trophectodermal cell differentiation Source: MGI
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