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Mouse Anti-HOPX Recombinant Antibody (DS14F5) (CBMAB-H2715-FY)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat, Pig, Cattle, Dog, Chicken, Guinea pig, Hamster, Rabbit, Sheep, Frog
Clone
DS14F5
Antibody Isotype
IgG1
Application
WB, IHC, IP, IHC-P

Basic Information

Immunogen
Chicken HOP
Specificity
Human, Mouse, Rat, Pig, Cattle, Dog, Chicken, Guinea pig, Hamster, Rabbit, Sheep, Frog
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
HOPX
Introduction
The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggest that this protein may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene expression and cardiac development. Multiple alternatively spliced transcript variants have been identified for this gene.
Entrez Gene ID
Human84525
Mouse74318
Rat171160
Pig396692
Hamster101840480
Cattle281270
Dog100855799
Chicken395241
Guinea pig100728620
Rabbit100037714
Sheep101118190
Frog780767
UniProt ID
HumanQ9BPY8
MouseQ8R1H0
RatQ78ZR5
PigQ8MJD6
HamsterA0A1U7QKE3
CattleQ8MJD5
DogJ9NZB1
ChickenQ8JHU0
Guinea pigA0A286Y2S7
RabbitG1SN79
SheepA0A6P3TEU5
FrogQ0V9C1
Alternative Names
HOP Homeobox; Lung Cancer-Associated Y Protein; Odd Homeobox Protein 1; NECC1; LAGY; HOD; HOP; OB1
Function
Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity).

May act as a tumor suppressor. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding (PubMed:27708256).
Biological Process
Bundle of His development Source: BHF-UCL
Chaperone-mediated protein complex assembly Source: CAFA
Histone deacetylation Source: Ensembl
Lung alveolus development Source: Ensembl
Negative regulation of cell differentiation Source: MGI
Negative regulation of transcription by RNA polymerase II Source: Ensembl
Positive regulation of skeletal muscle tissue regeneration Source: Ensembl
Positive regulation of striated muscle cell differentiation Source: Ensembl
Regulation of heart contraction Source: Ensembl
Regulation of protein binding Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Trophectodermal cell differentiation Source: MGI
Cellular Location
Nucleus; Cytoplasm
More Infomation

Caspa Gokulan, R., Yap, L. F., & Paterson, I. C. (2022). HOPX: A Unique Homeodomain Protein in Development and Tumor Suppression. Cancers, 14(11), 2764.

He, S., Ding, Y., Ji, Z., Yuan, B., Chen, J., & Ren, W. (2023). HOPX is a tumor-suppressive biomarker that corresponds to T cell infiltration in skin cutaneous melanoma. Cancer Cell International, 23(1), 1-16.

Hng, C. H., Camp, E., Anderson, P., Breen, J., Zannettino, A., & Gronthos, S. (2020). HOPX regulates bone marrow-derived mesenchymal stromal cell fate determination via suppression of adipogenic gene pathways. Scientific reports, 10(1), 11345.

Liu, Y., & Zhang, W. (2020). The role of HOPX in normal tissues and tumor progression. Bioscience reports, 40(1), BSR20191953.

Lin, C. C., Yao, C. Y., Hsu, Y. C., Hou, H. A., Yuan, C. T., Li, Y. H., ... & Tien, H. F. (2020). Knock-out of Hopx disrupts stemness and quiescence of hematopoietic stem cells in mice. Oncogene, 39(28), 5112-5123.

Liang, H., Wang, C., Gao, K., Li, J., & Jia, R. (2019). ΜicroRNA‑421 promotes the progression of non‑small cell lung cancer by targeting HOPX and regulating the Wnt/β‑catenin signaling pathway. Molecular Medicine Reports, 20(1), 151-161.

Ota, C., Ng-Blichfeldt, J. P., Korfei, M., Alsafadi, H. N., Lehmann, M., Skronska-Wasek, W., ... & Königshoff, M. (2018). Dynamic expression of HOPX in alveolar epithelial cells reflects injury and repair during the progression of pulmonary fibrosis. Scientific reports, 8(1), 12983.

Vaid, S., Camp, J. G., Hersemann, L., Eugster Oegema, C., Heninger, A. K., Winkler, S., ... & Namba, T. (2018). A novel population of Hopx-dependent basal radial glial cells in the developing mouse neocortex. Development, 145(20), dev169276.

Friedman, C. E., Nguyen, Q., Lukowski, S. W., Helfer, A., Chiu, H. S., Miklas, J., ... & Palpant, N. J. (2018). Single-cell transcriptomic analysis of cardiac differentiation from human PSCs reveals HOPX-dependent cardiomyocyte maturation. Cell stem cell, 23(4), 586-598.

Zweifel, S., Marcy, G., Guidice, Q. L., Li, D., Heinrich, C., Azim, K., & Raineteau, O. (2018). HOPX defines heterogeneity of postnatal subventricular zone neural stem cells. Stem cell reports, 11(3), 770-783.

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For research use only. Not intended for any clinical use.

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