HES6

This gene encodes a member of a subfamily of basic helix-loop-helix transcription repressors that have homology to the Drosophila enhancer of split genes. Members of this gene family regulate cell differentiation in numerous cell types. The protein encoded by this gene functions as a cofactor, interacting with other transcription factors through a tetrapeptide domain in its C-terminus. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Dec 2008]

Hes Family BHLH Transcription Factor 6

Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation (By similarity).

Anterior/posterior pattern specification Source: GO_Central
Negative regulation of DNA-binding transcription factor activity Source: ARUK-UCL
Regulation of neurogenesis Source: GO_Central
Regulation of transcription, DNA-templated Source: ProtInc
Regulation of transcription by RNA polymerase II Source: GO_Central

Nucleus