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Mouse Anti-HES6 Recombinant Antibody (CBFYH-0965) (CBMAB-H1904-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-0965
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Full length human recombinant protein of human HES6 produced in E. coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Hes Family BHLH Transcription Factor 6
Introduction
This gene encodes a member of a subfamily of basic helix-loop-helix transcription repressors that have homology to the Drosophila enhancer of split genes. Members of this gene family regulate cell differentiation in numerous cell types. The protein encoded by this gene functions as a cofactor, interacting with other transcription factors through a tetrapeptide domain in its C-terminus. Alternatively spliced transcript variants encoding different isoforms have been described.
Entrez Gene ID
55502
UniProt ID
Q96HZ4
Alternative Names
Hes Family BHLH Transcription Factor 6; Class B Basic Helix-Loop-Helix Protein 41; Hairy And Enhancer Of Split 6; C-HAIRY1; BHLHb41; Hairy And Enhancer Of Split 6 (Drosophila); Transcription Cofactor HES-6; BHLHc23; HES-6
Function
Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation (By similarity).
Biological Process
Anterior/posterior pattern specification Source: GO_Central
Negative regulation of DNA-binding transcription factor activity Source: ARUK-UCL
Regulation of neurogenesis Source: GO_Central
Regulation of transcription, DNA-templated Source: ProtInc
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

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