HDAC6

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008]

HDAC6

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:10220385).

Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed:10220385).

Histone deacetylases act via the formation of large multiprotein complexes (PubMed:10220385).

In addition to histones, deacetylates other proteins: plays a central role in microtubule-dependent cell motility by mediating deacetylation of tubulin (PubMed:12024216, PubMed:20308065).

Promotes deacetylation of CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy (PubMed:30538141).

Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer (PubMed:24413532).

In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome (PubMed:17846173).

Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy (PubMed:17846173).

Aggresome assembly Source: BHF-UCL
Autophagy Source: UniProtKB-KW
Axonal transport of mitochondrion Source: ARUK-UCL
Cellular response to hydrogen peroxide Source: BHF-UCL
Cellular response to misfolded protein Source: Ensembl
Cellular response to topologically incorrect protein Source: BHF-UCL
Cilium assembly Source: Reactome
Collateral sprouting Source: Ensembl
Dendritic spine morphogenesis Source: Ensembl
Histone deacetylation Source: BHF-UCL
Hsp90 deacetylation Source: Ensembl
Intracellular protein transport Source: BHF-UCL
Lysosome localization Source: BHF-UCL
Negative regulation of hydrogen peroxide metabolic process Source: BHF-UCL
Negative regulation of microtubule depolymerization Source: Ensembl
Negative regulation of oxidoreductase activity Source: BHF-UCL
Negative regulation of protein-containing complex assembly Source: ARUK-UCL
Negative regulation of protein-containing complex disassembly Source: BHF-UCL
Negative regulation of proteolysis Source: BHF-UCL
Negative regulation of transcription, DNA-templated Source: UniProtKB
Parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization Source: ParkinsonsUK-UCL
Peptidyl-lysine deacetylation Source: BHF-UCL
Polyubiquitinated misfolded protein transport Source: BHF-UCL
Positive regulation of epithelial cell migration Source: BHF-UCL
Positive regulation of hydrogen peroxide-mediated programmed cell death Source: BHF-UCL
Positive regulation of peptidyl-serine phosphorylation Source: ARUK-UCL
Positive regulation of signaling receptor activity Source: BHF-UCL
Protein-containing complex disassembly Source: Ensembl
Protein deacetylation Source: UniProtKB
Protein destabilization Source: Ensembl
Protein polyubiquitination Source: Ensembl
Protein quality control for misfolded or incompletely synthesized proteins Source: BHF-UCL
Regulation of androgen receptor signaling pathway Source: BHF-UCL
Regulation of autophagy Source: ParkinsonsUK-UCL
Regulation of autophagy of mitochondrion Source: ParkinsonsUK-UCL
Regulation of establishment of protein localization Source: Ensembl
Regulation of fat cell differentiation Source: Ensembl
Regulation of gene expression, epigenetic Source: UniProtKB
Regulation of macroautophagy Source: BHF-UCL
Regulation of microtubule-based movement Source: BHF-UCL
Regulation of protein stability Source: ParkinsonsUK-UCL
Response to growth factor Source: BHF-UCL
Response to misfolded protein Source: BHF-UCL
Tubulin deacetylation Source: UniProtKB
Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source: Ensembl

Cytoplasm; Nucleus; Cytoskeleton; Perikaryon; Dendrite; Axon. It is mainly cytoplasmic, where it is associated with microtubules.

Chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia (CDP-PBHM):
A disease characterized by chondrodysplasia, severe platyspondyly, hydrocephaly, and facial features with microphthalmia. Bone abnormalities include a distinctive metaphyseal cupping of the metacarpals, metatarsals, and phalanges. Affected females show a milder phenotype with small stature, sometimes associated with body asymmetry and mild mental retardation.

Phosphorylated by AURKA.
Ubiquitinated. Its polyubiquitination however does not lead to its degradation.
Sumoylated in vitro.